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A5UCB3

- DAPB_HAEIE

UniProt

A5UCB3 - DAPB_HAEIE

Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene

dapB

Organism
Haemophilus influenzae (strain PittEE)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.UniRule annotation

    Catalytic activityi

    (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351NADUniRule annotation
    Binding sitei36 – 361NADPUniRule annotation
    Active sitei156 – 1561Proton donor/acceptorUniRule annotation
    Binding sitei157 – 1571SubstrateUniRule annotation
    Active sitei160 – 1601Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146NAD(P)UniRule annotation
    Nucleotide bindingi99 – 1013NAD(P)UniRule annotation
    Nucleotide bindingi123 – 1264NAD(P)UniRule annotation

    GO - Molecular functioni

    1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADPH binding Source: InterPro
    4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciHINF374930:GJDD-975-MONOMER.
    UniPathwayiUPA00034; UER00018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation (EC:1.17.1.8UniRule annotation)
    Short name:
    HTPA reductaseUniRule annotation
    Gene namesi
    Name:dapBUniRule annotation
    Ordered Locus Names:CGSHiEE_05135
    OrganismiHaemophilus influenzae (strain PittEE)
    Taxonomic identifieri374930 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000006555: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2702704-hydroxy-tetrahydrodipicolinate reductasePRO_1000008567Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi374930.CGSHiEE_05135.

    Structurei

    3D structure databases

    ProteinModelPortaliA5UCB3.
    SMRiA5UCB3. Positions 3-270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni166 – 1672Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DapB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0289.
    HOGENOMiHOG000227153.
    KOiK00215.
    OMAiHTVWFAD.
    OrthoDBiEOG6SV5DS.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00102. DapB.
    InterProiIPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR20836. PTHR20836. 1 hit.
    PfamiPF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000161. DHPR. 1 hit.
    TIGRFAMsiTIGR00036. dapB. 1 hit.
    PROSITEiPS01298. DAPB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5UCB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLKIAIAGA GGRMGRQLIQ AVHSAEGVEL GAAFERKGSS LVGTDAGELA    50
    GIGHLGVAVS DDLESQKDKF DLLIDFTRPE GSLEHIAFCV ANNKKMVIGT 100
    TGFDQNGKAA IKAASDKIAI VFASNFSVGV NLVFKLLEKA AKVMGDYCDI 150
    EVIEAHHRHK VDAPSGTALS MGEHIAKTLG RDLKTHGVFC REGITGERKR 200
    DEIGFSTIRA SDVVGEHMVW FADIGERVEI SHKASSRMTF ANGAVRAGKW 250
    LENKANGLFD MTDVLDLNNL 270
    Length:270
    Mass (Da):28,923
    Last modified:July 10, 2007 - v1
    Checksum:i07932E5133CFDF0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000671 Genomic DNA. Translation: ABQ98414.1.
    RefSeqiWP_012054396.1. NC_009566.1.
    YP_001290797.1. NC_009566.1.

    Genome annotation databases

    EnsemblBacteriaiABQ98414; ABQ98414; CGSHiEE_05135.
    GeneIDi5226204.
    KEGGihip:CGSHiEE_05135.
    PATRICi20278185. VBIHaeInf81350_1035.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000671 Genomic DNA. Translation: ABQ98414.1 .
    RefSeqi WP_012054396.1. NC_009566.1.
    YP_001290797.1. NC_009566.1.

    3D structure databases

    ProteinModelPortali A5UCB3.
    SMRi A5UCB3. Positions 3-270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374930.CGSHiEE_05135.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ98414 ; ABQ98414 ; CGSHiEE_05135 .
    GeneIDi 5226204.
    KEGGi hip:CGSHiEE_05135.
    PATRICi 20278185. VBIHaeInf81350_1035.

    Phylogenomic databases

    eggNOGi COG0289.
    HOGENOMi HOG000227153.
    KOi K00215.
    OMAi HTVWFAD.
    OrthoDBi EOG6SV5DS.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00018 .
    BioCyci HINF374930:GJDD-975-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00102. DapB.
    InterProi IPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR20836. PTHR20836. 1 hit.
    Pfami PF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000161. DHPR. 1 hit.
    TIGRFAMsi TIGR00036. dapB. 1 hit.
    PROSITEi PS01298. DAPB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
      Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
      Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PittEE.

    Entry informationi

    Entry nameiDAPB_HAEIE
    AccessioniPrimary (citable) accession number: A5UCB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.Curated

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3