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A5UCB3

- DAPB_HAEIE

UniProt

A5UCB3 - DAPB_HAEIE

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Protein
4-hydroxy-tetrahydrodipicolinate reductase
Gene
dapB, CGSHiEE_05135
Organism
Haemophilus influenzae (strain PittEE)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate By similarity.UniRule annotation

Catalytic activityi

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NAD By similarity
Binding sitei36 – 361NADP By similarity
Active sitei156 – 1561Proton donor/acceptor By similarity
Binding sitei157 – 1571Substrate By similarity
Active sitei160 – 1601Proton donor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NAD(P) By similarity
Nucleotide bindingi99 – 1013NAD(P) By similarity
Nucleotide bindingi123 – 1264NAD(P) By similarity

GO - Molecular functioni

  1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
  2. NAD binding Source: UniProtKB-HAMAP
  3. NADPH binding Source: InterPro
  4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciHINF374930:GJDD-975-MONOMER.
UniPathwayiUPA00034; UER00018.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-tetrahydrodipicolinate reductase (EC:1.17.1.8)
Short name:
HTPA reductase
Gene namesi
Name:dapB
Ordered Locus Names:CGSHiEE_05135
OrganismiHaemophilus influenzae (strain PittEE)
Taxonomic identifieri374930 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000006555: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2702704-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation
PRO_1000008567Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi374930.CGSHiEE_05135.

Structurei

3D structure databases

ProteinModelPortaliA5UCB3.
SMRiA5UCB3. Positions 3-270.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 1672Substrate binding By similarity

Sequence similaritiesi

Belongs to the DapB family.

Phylogenomic databases

eggNOGiCOG0289.
HOGENOMiHOG000227153.
KOiK00215.
OMAiHTVWFAD.
OrthoDBiEOG6SV5DS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00102. DapB.
InterProiIPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR20836. PTHR20836. 1 hit.
PfamiPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000161. DHPR. 1 hit.
TIGRFAMsiTIGR00036. dapB. 1 hit.
PROSITEiPS01298. DAPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5UCB3-1 [UniParc]FASTAAdd to Basket

« Hide

MTLKIAIAGA GGRMGRQLIQ AVHSAEGVEL GAAFERKGSS LVGTDAGELA    50
GIGHLGVAVS DDLESQKDKF DLLIDFTRPE GSLEHIAFCV ANNKKMVIGT 100
TGFDQNGKAA IKAASDKIAI VFASNFSVGV NLVFKLLEKA AKVMGDYCDI 150
EVIEAHHRHK VDAPSGTALS MGEHIAKTLG RDLKTHGVFC REGITGERKR 200
DEIGFSTIRA SDVVGEHMVW FADIGERVEI SHKASSRMTF ANGAVRAGKW 250
LENKANGLFD MTDVLDLNNL 270
Length:270
Mass (Da):28,923
Last modified:July 10, 2007 - v1
Checksum:i07932E5133CFDF0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000671 Genomic DNA. Translation: ABQ98414.1.
RefSeqiWP_012054396.1. NC_009566.1.
YP_001290797.1. NC_009566.1.

Genome annotation databases

EnsemblBacteriaiABQ98414; ABQ98414; CGSHiEE_05135.
GeneIDi5226204.
KEGGihip:CGSHiEE_05135.
PATRICi20278185. VBIHaeInf81350_1035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000671 Genomic DNA. Translation: ABQ98414.1 .
RefSeqi WP_012054396.1. NC_009566.1.
YP_001290797.1. NC_009566.1.

3D structure databases

ProteinModelPortali A5UCB3.
SMRi A5UCB3. Positions 3-270.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374930.CGSHiEE_05135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ98414 ; ABQ98414 ; CGSHiEE_05135 .
GeneIDi 5226204.
KEGGi hip:CGSHiEE_05135.
PATRICi 20278185. VBIHaeInf81350_1035.

Phylogenomic databases

eggNOGi COG0289.
HOGENOMi HOG000227153.
KOi K00215.
OMAi HTVWFAD.
OrthoDBi EOG6SV5DS.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00018 .
BioCyci HINF374930:GJDD-975-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00102. DapB.
InterProi IPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR20836. PTHR20836. 1 hit.
Pfami PF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000161. DHPR. 1 hit.
TIGRFAMsi TIGR00036. dapB. 1 hit.
PROSITEi PS01298. DAPB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
    Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
    Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PittEE.

Entry informationi

Entry nameiDAPB_HAEIE
AccessioniPrimary (citable) accession number: A5UCB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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