Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A5UC59

- GCH1_HAEIE

UniProt

A5UC59 - GCH1_HAEIE

Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Haemophilus influenzae (strain PittEE)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi109 – 1091ZincUniRule annotation
    Metal bindingi112 – 1121ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. one-carbon metabolic process Source: UniProtKB-HAMAP
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciHINF374930:GJDD-921-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
    Alternative name(s):
    GTP cyclohydrolase IUniRule annotation
    Short name:
    GTP-CH-IUniRule annotation
    Gene namesi
    Name:folEUniRule annotation
    Ordered Locus Names:CGSHiEE_04835
    OrganismiHaemophilus influenzae (strain PittEE)
    Taxonomic identifieri374930 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000006555: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218GTP cyclohydrolase 1PRO_1000043695Add
    BLAST

    Interactioni

    Subunit structurei

    Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

    Protein-protein interaction databases

    STRINGi374930.CGSHiEE_04835.

    Structurei

    3D structure databases

    ProteinModelPortaliA5UC59.
    SMRiA5UC59. Positions 4-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0302.
    HOGENOMiHOG000221222.
    KOiK01495.
    OMAiDECSHTI.
    OrthoDBiEOG6XHC8G.

    Family and domain databases

    HAMAPiMF_00223. FolE.
    InterProiIPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view]
    PANTHERiPTHR11109. PTHR11109. 1 hit.
    PfamiPF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00063. folE. 1 hit.
    PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5UC59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKISLDALN VRNALIEKGI ETPMIDPTQA KDERRESIAK HMHEVMKLIG    50
    LDLRDDSLEE TPNRLAKMFI DEIFSGMDYA NFPKMTKIKN QMKVSEMVQV 100
    NDITLTSTCE HHFVTIDGKV CVAYYPKDWV IGLSKINRIV SFFAQRPQVQ 150
    ERLTEQLLTA FQTILETDDV AVYVKATHFC VKARGIRDTN SYTVTSAYGG 200
    VFLEDRDTRK EFLATVQK 218
    Length:218
    Mass (Da):24,946
    Last modified:July 10, 2007 - v1
    Checksum:iBCC8EBEA3CFB69D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000671 Genomic DNA. Translation: ABQ98360.1.
    RefSeqiYP_001290743.1. NC_009566.1.

    Genome annotation databases

    EnsemblBacteriaiABQ98360; ABQ98360; CGSHiEE_04835.
    GeneIDi5225371.
    KEGGihip:CGSHiEE_04835.
    PATRICi20278063. VBIHaeInf81350_0974.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000671 Genomic DNA. Translation: ABQ98360.1 .
    RefSeqi YP_001290743.1. NC_009566.1.

    3D structure databases

    ProteinModelPortali A5UC59.
    SMRi A5UC59. Positions 4-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374930.CGSHiEE_04835.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ98360 ; ABQ98360 ; CGSHiEE_04835 .
    GeneIDi 5225371.
    KEGGi hip:CGSHiEE_04835.
    PATRICi 20278063. VBIHaeInf81350_0974.

    Phylogenomic databases

    eggNOGi COG0302.
    HOGENOMi HOG000221222.
    KOi K01495.
    OMAi DECSHTI.
    OrthoDBi EOG6XHC8G.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci HINF374930:GJDD-921-MONOMER.

    Family and domain databases

    HAMAPi MF_00223. FolE.
    InterProi IPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view ]
    PANTHERi PTHR11109. PTHR11109. 1 hit.
    Pfami PF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00063. folE. 1 hit.
    PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
      Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
      Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PittEE.

    Entry informationi

    Entry nameiGCH1_HAEIE
    AccessioniPrimary (citable) accession number: A5UC59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3