Reviewed, UniProtKB/Swiss-Prot A5UBV9 (CDD_HAEIE)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	CGSHiEE_04275

Organism

Haemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP]

Taxonomic identifier

374930 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Cytidine deaminase HAMAP MF_01558		PRO_1000068955
Regions
	Region	88 – 90	3	Substrate binding By similarity
Sites
	Active site	103	1	Proton donor By similarity
	Metal binding	101	1	Zinc; catalytic By similarity
	Metal binding	128	1	Zinc; catalytic By similarity
	Metal binding	131	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5UBV9-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 27DEB7C0C7AFEACD	FASTA	292	32,611
	10 20 30 40 50 60 MQELIKRTLP QDDALNQAIV NELRSQNWAG FLNYSQVQQL CHNFELTPLK LAMHLLPLAA 70 80 90 100 110 120 SYSHTAISHF NVGAIAIGEQ GDFYFGANQE FANSAIQQTI HAEQSAISHA WLRNERRISD 130 140 150 160 170 180 MVVNYTPCGH CRQFMNELHG AEKISIHLPH SQNNPLHSYL PDAFGPKDLD IAAHLLADEN 190 200 210 220 230 240 HDLIADHQDD LINQAILAAN QSHCPYSNSP HGIAILFKNG DMVTGRYAEN AAFNPSLPAL 250 260 270 280 290 QTALNFAYLN DKKLSDIERI VMAEKALKLS HKTMAETLLS TLTSVELEYY SL

References

[1]

"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains." Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D. Genome Biol. 8:RESEARCH103.1-RESEARCH103.18(2007) [PubMed: 17550610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000671 Genomic DNA. Translation: ABQ98260.1.
RefSeq	YP_001290643.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5UBV9.
Genome annotation databases
GeneID	5225714.
GenomeReviews	Gene locus CGSHiEE_04275 in contig CP000671_GR.
KEGG	hip:CGSHiEE_04275.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FSPCGHC.
Family and domain databases
HAMAP	MF_01558. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR013171. Cyd/dCyd_deaminase_Zn_bd. IPR006263. Cyt_deam_dimer. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01355. cyt_deam_dimer. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_HAEIE

Accession

Primary (citable) accession number: A5UBV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 10, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)