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A5UBI6

- A5UBI6_HAEIE

UniProt

A5UBI6 - A5UBI6_HAEIE

Protein

Endonuclease III

Gene

modC

Organism
Haemophilus influenzae (strain PittEE)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity.UniRule annotation
    DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi187 – 1871Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi194 – 1941Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi197 – 1971Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi203 – 2031Iron-sulfur (4Fe-4S)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-KW
    3. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
    4. DNA binding Source: UniProtKB-HAMAP
    5. DNA N-glycosylase activity Source: UniProtKB-HAMAP
    6. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. base-excision repair Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotation, Hydrolase, LyaseUniRule annotation

    Keywords - Biological processi

    DNA damage, DNA repairUniRule annotation

    Keywords - Ligandi

    4Fe-4SUniRule annotation, ATP-bindingImported, DNA-bindingUniRule annotation, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHINF374930:GJDD-697-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endonuclease IIIUniRule annotation (EC:4.2.99.18UniRule annotation)
    Alternative name(s):
    DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation
    Gene namesi
    Name:modCImported
    Synonyms:nthUniRule annotation
    Ordered Locus Names:CGSHiEE_03590Imported
    OrganismiHaemophilus influenzae (strain PittEE)Imported
    Taxonomic identifieri374930 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000006555: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi374930.CGSHiEE_03590.

    Structurei

    3D structure databases

    ProteinModelPortaliA5UBI6.
    SMRiA5UBI6. Positions 1-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini100 – 12728HhHUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nth/MutY family.UniRule annotation
    Contains 1 HhH domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0177.
    HOGENOMiHOG000252206.
    KOiK10773.
    OMAiDTHIYRV.
    OrthoDBiEOG6H4KC5.

    Family and domain databases

    Gene3Di1.10.1670.10. 1 hit.
    1.10.340.30. 1 hit.
    HAMAPiMF_00942. Nth.
    InterProiIPR011257. DNA_glycosylase.
    IPR004036. Endonuclease-III-like_CS2.
    IPR004035. Endouclease-III_FeS-bd_BS.
    IPR003651. Endouclease3_FeS-loop_motif.
    IPR003265. HhH-GPD_domain.
    IPR000445. HhH_motif.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR023170. HTH_base_excis_C.
    IPR005759. Nth.
    [Graphical view]
    PfamiPF10576. EndIII_4Fe-2S. 1 hit.
    PF00633. HHH. 1 hit.
    PF00730. HhH-GPD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001435. Nth. 1 hit.
    SMARTiSM00478. ENDO3c. 1 hit.
    SM00525. FES. 1 hit.
    SM00278. HhH1. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.
    TIGRFAMsiTIGR01083. nth. 1 hit.
    PROSITEiPS00764. ENDONUCLEASE_III_1. 1 hit.
    PS01155. ENDONUCLEASE_III_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5UBI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKTKRIEIL TRLREQNPHP TTELQYNSPF ELLIAVILSA QATDKGVNKA    50
    TEKLFPVANT PQAILDLGLD GLKSYIKTIG LFNSKAENII KTCRDLIEKH 100
    NGEIPENREA LEALAGVGRK TANVVLNTAF GHPTIAVDTH IFRVCNRTNF 150
    AAGKDVVKVE EKLLKVVPNE FKVDVHHWLI LHGRYTCIAR KPRCGSCIIE 200
    DLCEYKEKVE F 211
    Length:211
    Mass (Da):23,730
    Last modified:July 10, 2007 - v1
    Checksum:i4C8AA5E618E0069F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000671 Genomic DNA. Translation: ABQ98137.1.
    RefSeqiYP_001290520.1. NC_009566.1.

    Genome annotation databases

    EnsemblBacteriaiABQ98137; ABQ98137; CGSHiEE_03590.
    GeneIDi5224918.
    KEGGihip:CGSHiEE_03590.
    PATRICi20277555. VBIHaeInf81350_0725.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000671 Genomic DNA. Translation: ABQ98137.1 .
    RefSeqi YP_001290520.1. NC_009566.1.

    3D structure databases

    ProteinModelPortali A5UBI6.
    SMRi A5UBI6. Positions 1-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374930.CGSHiEE_03590.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ98137 ; ABQ98137 ; CGSHiEE_03590 .
    GeneIDi 5224918.
    KEGGi hip:CGSHiEE_03590.
    PATRICi 20277555. VBIHaeInf81350_0725.

    Phylogenomic databases

    eggNOGi COG0177.
    HOGENOMi HOG000252206.
    KOi K10773.
    OMAi DTHIYRV.
    OrthoDBi EOG6H4KC5.

    Enzyme and pathway databases

    BioCyci HINF374930:GJDD-697-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1670.10. 1 hit.
    1.10.340.30. 1 hit.
    HAMAPi MF_00942. Nth.
    InterProi IPR011257. DNA_glycosylase.
    IPR004036. Endonuclease-III-like_CS2.
    IPR004035. Endouclease-III_FeS-bd_BS.
    IPR003651. Endouclease3_FeS-loop_motif.
    IPR003265. HhH-GPD_domain.
    IPR000445. HhH_motif.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR023170. HTH_base_excis_C.
    IPR005759. Nth.
    [Graphical view ]
    Pfami PF10576. EndIII_4Fe-2S. 1 hit.
    PF00633. HHH. 1 hit.
    PF00730. HhH-GPD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001435. Nth. 1 hit.
    SMARTi SM00478. ENDO3c. 1 hit.
    SM00525. FES. 1 hit.
    SM00278. HhH1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    TIGRFAMsi TIGR01083. nth. 1 hit.
    PROSITEi PS00764. ENDONUCLEASE_III_1. 1 hit.
    PS01155. ENDONUCLEASE_III_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
      Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
      Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PittEEImported.

    Entry informationi

    Entry nameiA5UBI6_HAEIE
    AccessioniPrimary (citable) accession number: A5UBI6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3