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A5UBI6 (A5UBI6_HAEIE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Endonuclease III PIRNR PIRNR001435 HAMAP-Rule MF_00942

EC=4.2.99.18 PIRNR PIRNR001435 HAMAP-Rule MF_00942
Alternative name(s):
DNA-(apurinic or apyrimidinic site) lyase HAMAP-Rule MF_00942
Gene names
Name:modC EMBL ABQ98137.1
Synonyms:nth HAMAP-Rule MF_00942
Ordered Locus Names:CGSHiEE_03590 EMBL ABQ98137.1
OrganismHaemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP] EMBL ABQ98137.1
Taxonomic identifier374930 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity By similarity. PIRNR PIRNR001435

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate By similarity. HAMAP-Rule MF_00942

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. PIRNR PIRNR001435 HAMAP-Rule MF_00942

Cofactor

Binds 1 4Fe-4S cluster By similarity. PIRNR PIRNR001435 HAMAP-Rule MF_00942

Sequence similarities

Belongs to the Nth/MutY family. PIRNR PIRNR001435 HAMAP-Rule MF_00942

Contains 1 HhH domain. HAMAP-Rule MF_00942

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain100 – 12728HhH By similarity HAMAP-Rule MF_00942

Sites

Metal binding1871Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding1941Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding1971Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding2031Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942

Sequences

Sequence LengthMass (Da)Tools
A5UBI6 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 4C8AA5E618E0069F

FASTA21123,730
        10         20         30         40         50         60 
MNKTKRIEIL TRLREQNPHP TTELQYNSPF ELLIAVILSA QATDKGVNKA TEKLFPVANT 

        70         80         90        100        110        120 
PQAILDLGLD GLKSYIKTIG LFNSKAENII KTCRDLIEKH NGEIPENREA LEALAGVGRK 

       130        140        150        160        170        180 
TANVVLNTAF GHPTIAVDTH IFRVCNRTNF AAGKDVVKVE EKLLKVVPNE FKVDVHHWLI 

       190        200        210 
LHGRYTCIAR KPRCGSCIIE DLCEYKEKVE F 

« Hide

References

[1]"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PittEE EMBL ABQ98137.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000671 Genomic DNA. Translation: ABQ98137.1.
RefSeqYP_001290520.1. NC_009566.1.

3D structure databases

ProteinModelPortalA5UBI6.
SMRA5UBI6. Positions 1-210.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING374930.CGSHiEE_03590.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ98137; ABQ98137; CGSHiEE_03590.
GeneID5224918.
KEGGhip:CGSHiEE_03590.
PATRIC20277555. VBIHaeInf81350_0725.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0177.
HOGENOMHOG000252206.
KOK10773.
OMADTHIYRV.
OrthoDBEOG6H4KC5.

Enzyme and pathway databases

BioCycHINF374930:GJDD-697-MONOMER.

Family and domain databases

Gene3D1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPMF_00942. Nth.
InterProIPR011257. DNA_glycosylase.
IPR004036. Endonuclease-III-like_CS2.
IPR004035. Endouclease-III_FeS-bd_BS.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
[Graphical view]
PfamPF10576. EndIII_4Fe-2S. 1 hit.
PF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFPIRSF001435. Nth. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
TIGRFAMsTIGR01083. nth. 1 hit.
PROSITEPS00764. ENDONUCLEASE_III_1. 1 hit.
PS01155. ENDONUCLEASE_III_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5UBI6_HAEIE
AccessionPrimary (citable) accession number: A5UBI6
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)