Reviewed, UniProtKB/Swiss-Prot A5UB85 (UXUA_HAEIE)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	CGSHiEE_03030

Organism

Haemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP]

Taxonomic identifier

374930 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Mannonate dehydratase HAMAP MF_00106		PRO_1000034329

Sequences

	Sequence		Length	Mass (Da)
	A5UB85-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 133D0B03ED73F304	FASTA	394	45,334
	10 20 30 40 50 60 MEQAWRWYGP KDPVSLSDIR QAGATGIVTA LHHIPNGEIW RIEEIKKRKT EIENAGLSWS 70 80 90 100 110 120 VVESVPVHEE IKTQTGNYQK WINNYKQTLR NLAQCGIDTV CYNFMPVLDW TRTDLAYELP 130 140 150 160 170 180 DGSKALRFDH IAFAAFELHI LKRPDAEKAY NQEEQVAART YYDKMSAQDI TQLTRNIIAG 190 200 210 220 230 240 LPGAEEGYTL DEFQTQLDRY KDISSEKFRT HLAYFLNEIV PVAQEVGIKM AIHPDDPPRP 250 260 270 280 290 300 ILGLPRIVST IEDMQWFVET QPLPANGFTM CTGSYGVRSD NDLVKMIEQF ADRIYFAHLR 310 320 330 340 350 360 STQREDNPLT FHKAAHLEGD VDMFNVVKAL LNEEYRRLNQ GETRLIPMRP DHGHQMLDDL 370 380 390 RKKTNPGYSA IGRLKGLAEF RGLEMALKKV YFNK

References

[1]

"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains." Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D. Genome Biol. 8:R103.1-R103.18(2007) [PubMed: 17550610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000671 Genomic DNA. Translation: ABQ98036.1.
RefSeq	YP_001290419.1.
3D structure databases
SMR	A5UB85. Positions 1-389.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UB85.
Genome annotation databases
GeneID	5224841.
GenomeReviews	Gene locus CGSHiEE_03030 in contig CP000671_GR.
KEGG	hip:CGSHiEE_03030.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1312.
HOGENOM	HBG585927.
OMA	VHEEIKT.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_HAEIE

Accession

Primary (citable) accession number: A5UB85

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	February 9, 2010
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)