A5UB71 (MUTL_HAEIE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein mutL

Gene names

Name:	mutL
Ordered Locus Names:	CGSHiEE_02960

Organism

Haemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP]

Taxonomic identifier

374930 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	629 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP MF_00149
Sequence similarities	Belongs to the DNA mismatch repair mutL/hexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 629	629	DNA mismatch repair protein mutL HAMAP MF_00149		PRO_1000010021

Sequences

	Sequence		Length	Mass (Da)
	A5UB71 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: D79308FF6C7AE1E7	FASTA	629	71,715
	10 20 30 40 50 60 MPIRILSPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAN KIQIDIENGG ANLIRIRDNG 70 80 90 100 110 120 CGIPKEELSL ALARHATSKI ADLDDLEAIL SLGFRGEALA SISSVSRLTL TSRTEEQTEA 130 140 150 160 170 180 WQVYAQGRDM ETTIKPASHP VGTTVEVANL FFNTPARRKF LRTDKTEFAH IDEVIRRIAL 190 200 210 220 230 240 TKFNTAFTLT HNGKIVRQYR PAFDLNQQLK RVAVICGDDF VKNALRIDWK HDDLHLSGWV 250 260 270 280 290 300 ATPNFSRTQN DLSYCYINGR MVRDKVISHA IRQAYAQYLP TDAYPAFVLF IDLNPHDVDV 310 320 330 340 350 360 NVHPTKHEVR FHQQRLIHDF IYEGISYALN NQEQLNWHTE QSAVENHEEN TVREPQPNYS 370 380 390 400 410 420 IRPNRAAAGQ NSFAPQYHEK PQQNQPHFSN TPVLPNHVST GYRDYRSDAP SKTEQRLYAE 430 440 450 460 470 480 LLRTLPPTAQ KDISNTAQQN ISDTAKIIST EIIECSSHLR ALSLIENRAL LLQQNQDFFL 490 500 510 520 530 540 LSLEKLQRLQ WQLALQQIQI EQQPLLIPIV FRLTEAQFQA WQQYSDNFKK IGFEFIENQA 550 560 570 580 590 600 QLRLTLNKVP NVLRTQNLQK CVMAMLTRDE NSSPFLTALC AQLECKTFDA LADALNLLSE 610 620 TERLLTQTNR TAFTQLLKPV NWQPLLDEI

References

[1]

"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains." Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D. Genome Biol. 8:R103.1-R103.18(2007) [PubMed: 17550610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PittEE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000671 Genomic DNA. Translation: ABQ98022.1.
RefSeq	YP_001290405.1. NC_009566.1.
3D structure databases
ProteinModelPortal	A5UB71.
SMR	A5UB71. Positions 1-325.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UB71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5225872.
GenomeReviews	Gene locus CGSHiEE_02960 in contig CP000671_GR.
KEGG	hip:CGSHiEE_02960.
PATRIC	20277288. VBIHaeInf81350_0600.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0323.
HOGENOM	HBG520262.
OMA	EVANLFF.
ProtClustDB	PRK00095.
Enzyme and pathway databases
BioCyc	HINF374930:CGSHIEE_02960-MONOMER.
Family and domain databases
HAMAP	MF_00149. DNA_mis_repair. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K03572.
PANTHER	PTHR10073. DNA_mis_repair. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. Mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_HAEIE

Accession

Primary (citable) accession number: A5UB71

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program