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A5UAU8 (AROB_HAEIE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:CGSHiEE_02200
OrganismHaemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP]
Taxonomic identifier374930 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3623623-dehydroquinate synthase HAMAP MF_00110
PRO_1000094526

Sequences

Sequence LengthMass (Da)Tools
A5UAU8 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 5A7C62BF8C47A6E4

FASTA36239,780
        10         20         30         40         50         60 
MLCVNVELQE RRYPILIGSG LLQDERSYPI KRGGRVMIVT NPTVAQFYLD TVIYALEKRG 

        70         80         90        100        110        120 
CVVDHVLLPD GEKYKTLESL NLIFTALLQG NHGRDTTIIA LGGGVIGDVA GFAAASYQRG 

       130        140        150        160        170        180 
VRLIQIPTTL LSQVDSSVGG KTAVNHELGK NMIGAFYQPS MVIIDTLTLN TLPKREVNAG 

       190        200        210        220        230        240 
LAEVIKYGAI LDYEFFEWLE QHIDELVALN PEALQHCISR CCQIKADVVA RDETEKGDRA 

       250        260        270        280        290        300 
LLNLGHTFGH AIETHLGYGN WLHGEAVSTG MMMAAALSEE LGDISIADVS RLEKLLARAN 

       310        320        330        340        350        360 
LPTVSPDTMQ PEDYLPHMMR DKKVLSGKLR LVLLKSLGQA YVANDTAHTL VLNAIRRCTQ 


TD

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References

[1]"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
Genome Biol. 8:R103.1-R103.18(2007) [PubMed: 17550610] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PittEE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000671 Genomic DNA. Translation: ABQ97899.1.
RefSeqYP_001290282.1. NC_009566.1.

3D structure databases

ProteinModelPortalA5UAU8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5UAU8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5224937.
GenomeReviewsGene locus CGSHiEE_02200 in contig CP000671_GR.
KEGGhip:CGSHiEE_02200.
PATRIC20276934. VBIHaeInf81350_0444.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAGTFTQPD.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycHINF374930:CGSHIEE_02200-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_HAEIE
AccessionPrimary (citable) accession number: A5UAU8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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