Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-fucose isomerase

Gene

fucI

Organism
Haemophilus influenzae (strain PittEE)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei340Proton acceptorUniRule annotation1
Metal bindingi340ManganeseUniRule annotation1
Active sitei364Proton acceptorUniRule annotation1
Metal bindingi364ManganeseUniRule annotation1
Metal bindingi527ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciHINF374930:G1G8O-411-MONOMER
UniPathwayiUPA00563; UER00624

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:CGSHiEE_02050
OrganismiHaemophilus influenzae (strain PittEE)
Taxonomic identifieri374930 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000672211 – 589L-fucose isomeraseAdd BLAST589

Structurei

3D structure databases

ProteinModelPortaliA5UAS8
SMRiA5UAS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249674
KOiK01818
OMAiHAQKGLP

Family and domain databases

Gene3Di3.20.14.10, 1 hit
3.40.275.10, 1 hit
3.40.50.1070, 1 hit
HAMAPiMF_01254 Fucose_iso, 1 hit
InterProiView protein in InterPro
IPR004216 Fuc/Ara_isomerase_C
IPR038393 Fuc_iso_dom3_sf
IPR015888 Fuc_isomerase_C
IPR038391 Fucose_iso_dom1_sf
IPR012888 Fucose_iso_N1
IPR005763 Fucose_isomerase
IPR038392 Fucose_isomerase_dom2_sf
IPR009015 Fucose_isomerase_N/cen_sf
IPR012889 Fucose_isomerase_N2
PfamiView protein in Pfam
PF02952 Fucose_iso_C, 1 hit
PF07881 Fucose_iso_N1, 1 hit
PF07882 Fucose_iso_N2, 1 hit
SUPFAMiSSF50443 SSF50443, 1 hit
SSF53743 SSF53743, 1 hit
TIGRFAMsiTIGR01089 fucI, 1 hit

Sequencei

Sequence statusi: Complete.

A5UAS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALATQSNRI KIGIRPTIDG RRMGVRESLE TQTIRMAQSV AQLLQTHIRY
60 70 80 90 100
TDSTFVECVV ADSTIGGVAE AAACADKFKR ENVGLTITVT PCWCYGSETI
110 120 130 140 150
DMDPHMPKAI WGFNGTERPG AVYLAAALAG HSQLGLPAFS IYGTEVQEAD
160 170 180 190 200
DTNIPEDVKE KLLRFARAGL AVASIRGKSY LSIGSVSMGI AGSIVNQAFF
210 220 230 240 250
QEYLGMRNEY VDMMEIKRRL DRKIYDQEEV DLALSWVKQY CKEGVDVNSL
260 270 280 290 300
ENQRNAEERA ELWENVVKMT IITRDLMVGN PKLATLNYAE EALGHNAIAA
310 320 330 340 350
GFQGQRHWTD HLPNGDFMEA MLNSTYDWNG VRPPYILATE NDSLNAIGML
360 370 380 390 400
FGHQLTGKAQ IFADVRTYWS QDSVERVTGW RPESGFIHLI NSGSAALDGT
410 420 430 440 450
GEHQDAQGNP TLKPAWDVTE EEAKRCLENT RWCPAVHEYF RGGGLSSQFL
460 470 480 490 500
TKGGIPFTMH RINLIKGLGP VLQIAEGWSI DLPQDVHNKL NQRTNETWPT
510 520 530 540 550
TWFVPRLTGK GAFTDVYSVM ANWGANHCVA THGHVGADLI TLASMLRIPV
560 570 580
CMHNVSEKNI FRPSAWNGFG QDKEGQDYRA CQNFGPLYK
Length:589
Mass (Da):65,475
Last modified:July 10, 2007 - v1
Checksum:iF1C2B26D06E2F6F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000671 Genomic DNA Translation: ABQ97879.1

Genome annotation databases

EnsemblBacteriaiABQ97879; ABQ97879; CGSHiEE_02050
KEGGihip:CGSHiEE_02050

Similar proteinsi

Entry informationi

Entry nameiFUCI_HAEIE
AccessioniPrimary (citable) accession number: A5UAS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health