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A5UA57 (NUDC_HAEIE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH pyrophosphatase
EC=3.6.1.22
Gene names
Name:nudC
Ordered Locus Names:CGSHiEE_00830
OrganismHaemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP]
Taxonomic identifier374930 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

NAD+ + H2O = AMP + NMN. HAMAP MF_00297

Cofactor

Divalent metal cations. Magnesium or manganese By similarity.

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00297

Subunit structure

Homodimer By similarity. HAMAP MF_00297

Sequence similarities

Belongs to the Nudix hydrolase family. NudC subfamily.

Contains 1 nudix hydrolase domain.

Ontologies

Keywords
   LigandMagnesium
Manganese
Metal-binding
NAD
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionNAD+ diphosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264NADH pyrophosphatase HAMAP MF_00297
PRO_1000071958

Regions

Domain126 – 253128Nudix hydrolase
Motif163 – 18422Nudix box HAMAP MF_00297

Sites

Metal binding991Zinc By similarity
Metal binding1021Zinc By similarity
Metal binding1171Zinc By similarity
Metal binding1201Zinc By similarity
Metal binding1781Divalent metal cation By similarity
Metal binding1821Divalent metal cation By similarity

Sequences

Sequence LengthMass (Da)Tools
A5UA57 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: F3807E750450B7CB

FASTA26430,206
        10         20         30         40         50         60 
MKILQQDDFG YWLLTQGSNL YLVNNELPFG IAKDIDLEGL QAMQIGEWKN HPLWLVAEQE 

        70         80         90        100        110        120 
SDEREYVSLR NLLSLPEDEF HILSRGVEIN HFLKTHKFCG KCGHKTQQTQ DELAVQCIHC 

       130        140        150        160        170        180 
GYQTYPVICP SIIVAVRRGH EILLANHKRH YSPNGGIYTT LAGFVEVGET FEQAVQREVF 

       190        200        210        220        230        240 
EETGISIKNL RYFGSQPWAF PNSQMVGFLA DYESGEITLQ ESEIHDAQWF SYDQPLPELP 

       250        260 
PTGTIARKLI HVTLELCKAE HKCD

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References

[1]"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
Genome Biol. 8:R103.1-R103.18(2007) [PubMed: 17550610] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PittEE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000671 Genomic DNA. Translation: ABQ97658.1.
RefSeqYP_001290041.1. NC_009566.1.

3D structure databases

ProteinModelPortalA5UA57.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5UA57.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5225424.
GenomeReviewsGene locus CGSHiEE_00830 in contig CP000671_GR.
KEGGhip:CGSHiEE_00830.
PATRIC20276330. VBIHaeInf81350_0166.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2816.
HOGENOMHBG736436.
OMAPHSLMMG.
ProtClustDBPRK00241.

Enzyme and pathway databases

BioCycHINF374930:CGSHIEE_00830-MONOMER.

Family and domain databases

HAMAPMF_00297. Nudix_NudC.
[Tree]
InterProIPR015375. NADH_PPase-like_N.
IPR022925. NADH_pyroPase_NudC.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR015376. Znr_NADH_PPase.
[Graphical view]
Gene3DG3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
KOK03426.
PfamPF00293. NUDIX. 1 hit.
PF09296. NUDIX-like. 1 hit.
PF09297. zf-NADH-PPase. 1 hit.
[Graphical view]
SUPFAMSSF55811. NUDIX_hydrolase. 2 hits.
PROSITEPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUDC_HAEIE
AccessionPrimary (citable) accession number: A5UA57
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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