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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Haemophilus influenzae (strain PittEE)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciHINF374930:GJDD-128-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:CGSHiEE_00695
OrganismiHaemophilus influenzae (strain PittEE)
Taxonomic identifieri374930 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Bifunctional protein PyrRPRO_1000053838Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA5UA30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi100 – 11213PRPP-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000245770.
KOiK02825.
OMAiVPTSRKE.
OrthoDBiEOG61VZD8.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

A5UA30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIIIDHDR FLRTISRISH EIIEKHQTLD DLVIVGIKRR GAEIAELLQR
60 70 80 90 100
RVEELSGINL PSMELDITFY RDDLTLVDQE DKMPVYSGSS QYLNIQDKTV
110 120 130 140 150
ILVDDVLFTG RTIRAAMDAL TDFGRAAKIE LVIFVDRGHR ELPIRADYVG
160 170
KNVPTSRDEL VQVRTEKQDG CYEVAILGK
Length:179
Mass (Da):20,498
Last modified:July 10, 2007 - v1
Checksum:i03569EE784C0A9E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000671 Genomic DNA. Translation: ABQ97631.1.
RefSeqiWP_005626142.1. NC_009566.1.

Genome annotation databases

EnsemblBacteriaiABQ97631; ABQ97631; CGSHiEE_00695.
KEGGihip:CGSHiEE_00695.
PATRICi20276274. VBIHaeInf81350_0139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000671 Genomic DNA. Translation: ABQ97631.1.
RefSeqiWP_005626142.1. NC_009566.1.

3D structure databases

ProteinModelPortaliA5UA30.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ97631; ABQ97631; CGSHiEE_00695.
KEGGihip:CGSHiEE_00695.
PATRICi20276274. VBIHaeInf81350_0139.

Phylogenomic databases

HOGENOMiHOG000245770.
KOiK02825.
OMAiVPTSRKE.
OrthoDBiEOG61VZD8.

Enzyme and pathway databases

BioCyciHINF374930:GJDD-128-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
    Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
    Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PittEE.

Entry informationi

Entry nameiPYRR_HAEIE
AccessioniPrimary (citable) accession number: A5UA30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: November 11, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.