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A5U9Z9

- LUXS_HAEIE

UniProt

A5U9Z9 - LUXS_HAEIE

Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Haemophilus influenzae (strain PittEE)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

    Catalytic activityi

    S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

    Cofactori

    Binds 1 iron ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541IronUniRule annotation
    Metal bindingi58 – 581IronUniRule annotation
    Metal bindingi128 – 1281IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. quorum sensing Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Autoinducer synthesis, Quorum sensing

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciHINF374930:GJDD-97-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
    Alternative name(s):
    AI-2 synthesis proteinUniRule annotation
    Autoinducer-2 production protein LuxSUniRule annotation
    Gene namesi
    Name:luxSUniRule annotation
    Ordered Locus Names:CGSHiEE_00530
    OrganismiHaemophilus influenzae (strain PittEE)
    Taxonomic identifieri374930 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000006555: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 167167S-ribosylhomocysteine lyasePRO_1000004844Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi374930.CGSHiEE_00530.

    Structurei

    3D structure databases

    ProteinModelPortaliA5U9Z9.
    SMRiA5U9Z9. Positions 3-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LuxS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1854.
    HOGENOMiHOG000040371.
    KOiK07173.
    OMAiRDHLNSD.
    OrthoDBiEOG68WRBM.

    Family and domain databases

    Gene3Di3.30.1360.80. 1 hit.
    HAMAPiMF_00091. LuxS.
    InterProiIPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view]
    PfamiPF02664. LuxS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006160. AI2. 1 hit.
    PRINTSiPR01487. LUXSPROTEIN.
    ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF63411. SSF63411. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5U9Z9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLLDSFKVD HTKMNAPAVR IAKTMRTPKG DNITVFDLRF CIPNKEILSP    50
    KGIHTLEHLF AGFMRDHLNG DSIEIIDISP MGCRTGFYMS LIGTPNEQEV 100
    SEAWLASMQD VLGVQDQASI PELNIYQCGS YTEHSLEDAH EIAKNVIARG 150
    IGVNKNEDLS LDNSLLK 167
    Length:167
    Mass (Da):18,571
    Last modified:July 10, 2007 - v1
    Checksum:i14076FFED42389A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000671 Genomic DNA. Translation: ABQ97600.1.
    RefSeqiYP_001289983.1. NC_009566.1.

    Genome annotation databases

    EnsemblBacteriaiABQ97600; ABQ97600; CGSHiEE_00530.
    GeneIDi5224877.
    KEGGihip:CGSHiEE_00530.
    PATRICi20276204. VBIHaeInf81350_0104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000671 Genomic DNA. Translation: ABQ97600.1 .
    RefSeqi YP_001289983.1. NC_009566.1.

    3D structure databases

    ProteinModelPortali A5U9Z9.
    SMRi A5U9Z9. Positions 3-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374930.CGSHiEE_00530.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ97600 ; ABQ97600 ; CGSHiEE_00530 .
    GeneIDi 5224877.
    KEGGi hip:CGSHiEE_00530.
    PATRICi 20276204. VBIHaeInf81350_0104.

    Phylogenomic databases

    eggNOGi COG1854.
    HOGENOMi HOG000040371.
    KOi K07173.
    OMAi RDHLNSD.
    OrthoDBi EOG68WRBM.

    Enzyme and pathway databases

    BioCyci HINF374930:GJDD-97-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.80. 1 hit.
    HAMAPi MF_00091. LuxS.
    InterProi IPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view ]
    Pfami PF02664. LuxS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006160. AI2. 1 hit.
    PRINTSi PR01487. LUXSPROTEIN.
    ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF63411. SSF63411. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
      Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
      Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PittEE.

    Entry informationi

    Entry nameiLUXS_HAEIE
    AccessioniPrimary (citable) accession number: A5U9Z9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3