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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Haemophilus influenzae (strain PittEE)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.UniRule annotation

Catalytic activityi

P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciHINF374930:G1G8O-45-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation (EC:3.6.1.41UniRule annotation)
Alternative name(s):
Ap4A hydrolaseUniRule annotation
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolaseUniRule annotation
Diadenosine tetraphosphataseUniRule annotation
Gene namesi
Name:apaHUniRule annotation
Ordered Locus Names:CGSHiEE_00220
OrganismiHaemophilus influenzae (strain PittEE)
Taxonomic identifieri374930 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000120621 – 275Bis(5'-nucleosyl)-tetraphosphatase, symmetricalAdd BLAST275

Structurei

3D structure databases

ProteinModelPortaliA5U9U1.
SMRiA5U9U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000251871.
KOiK01525.
OMAiMPWFDVP.

Family and domain databases

CDDicd07422. MPP_ApaH. 1 hit.
Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiView protein in InterPro
IPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

A5U9U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYFVGDLQ GCYDELQLLL ERVDFNPTQD KLYLVGDLVA RGDKSLECLR
60 70 80 90 100
FVKSLGNAAQ TVLGNHDLHL IATALDIKKV KPRDRVDAIF NAPDFDEQIH
110 120 130 140 150
WLRHQPLLVH SEELNFLMSH AGISPDWDLK TAKSCAAEVE QILQHGDFHY
160 170 180 190 200
LIENMYSEQP DRWSPDLQGL ARHRYIINAF TRMRFCYLDH RFDFACKSPL
210 220 230 240 250
KDAPAELTPW FNLDNPLYKQ IPIVFGHWAS LVDEPTPKGI YALDTGCVWN
260 270
NRMTMLRWED KQFFTQSAVK NYSDF
Length:275
Mass (Da):31,897
Last modified:July 10, 2007 - v1
Checksum:i4D0BEC668CA01F0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000671 Genomic DNA. Translation: ABQ97542.1.

Genome annotation databases

EnsemblBacteriaiABQ97542; ABQ97542; CGSHiEE_00220.
KEGGihip:CGSHiEE_00220.

Similar proteinsi

Entry informationi

Entry nameiAPAH_HAEIE
AccessioniPrimary (citable) accession number: A5U9U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program