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Protein

Probable transport protein MmpL8

Gene

mmpL8

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-3984-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transport protein MmpL8Curated
Gene namesi
Name:mmpL8
Ordered Locus Names:MRA_3863
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence analysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Transmembranei349 – 36921HelicalSequence analysisAdd
BLAST
Transmembranei400 – 42021HelicalSequence analysisAdd
BLAST
Transmembranei555 – 57521HelicalSequence analysisAdd
BLAST
Transmembranei874 – 89421HelicalSequence analysisAdd
BLAST
Transmembranei898 – 91821HelicalSequence analysisAdd
BLAST
Transmembranei930 – 95021HelicalSequence analysisAdd
BLAST
Transmembranei973 – 99321HelicalSequence analysisAdd
BLAST
Transmembranei996 – 101621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10891089Probable transport protein MmpL8PRO_0000314684Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi419947.MRA_3863.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000043539.
KOiK06994.
OMAiRRGWITP.
OrthoDBiEOG6RVFRF.

Family and domain databases

InterProiIPR004869. MMPL_dom.
IPR000731. SSD.
[Graphical view]
PfamiPF03176. MMPL. 2 hits.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5U9F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDVLMQPVR TPRPSTNLRS KPLRPTGDGG VFPRLGRLIV RRPWVVIAFW
60 70 80 90 100
VALAGLLAPT VPSLDAISQR HPVAILPSDA PVLVSTRQMT AAFREAGLQS
110 120 130 140 150
VAVVVLSDAK GLGAADERSY KELVDALRRD TRDVVMLQDF VTTPPLRELM
160 170 180 190 200
TSKDNQAWIL PVGLPGDLGS TQSKQAYARV ADIVEHQVAG STLTANLTGP
210 220 230 240 250
AATVADLNLT GQRDRSRIEF AITILLLVIL LIIYGNPITM VLPLITIGMS
260 270 280 290 300
VVVAQRLVAI AGLAGLGIAN QSIIFMSGMM VGAGTDYAVF LISRYHDYLR
310 320 330 340 350
QGADSDQAVK KALTSIGKVI AASAATVAIT FLGMVFTQLG ILKTVGPMLG
360 370 380 390 400
ISVAVVFFAA VTLLPALMVL TGRRGWIAPR RDLTRRFWRS SGVHIVRRPK
410 420 430 440 450
THLLASALVL VILAGCAGLA RYNYDDRKTL PASVESSIGY AALDKHFPSN
460 470 480 490 500
LIIPEYLFIQ SSTDLRTPKA LADLEQMVQR VSQVPGVAMV RGITRPAGRS
510 520 530 540 550
LEQARTSWQA GEVGSKLDEG SKQIAVHTGD IDKLAGGANL MASKLGDVRA
560 570 580 590 600
QVNRAISTVG GLIDALAYLQ DLLGGNRVLG ELEGAEKLIG SMRALGDTID
610 620 630 640 650
ADASFVANNT EWASPVLGAL DSSPMCTADP ACASARTELQ RLVTARDDGT
660 670 680 690 700
LAKISELARQ LQATRAVQTL AATVSGLRGA LATVIRAMGS LGMSSPGGVR
710 720 730 740 750
SKINLVNKGV NDLADGSRQL AEGVQLLVDQ VKKMGFGLGE ASAFLLAMKD
760 770 780 790 800
TATTPAMAGF YIPPELLSYA TGESVKAETM PSEYRDLLGG LNVDQLKKVA
810 820 830 840 850
AAFISPDGHS IRYLIQTDLN PFSTAAMDQI DAITAAARGA QPNTALADAK
860 870 880 890 900
VSVVGLPVVL KDTRDYSDHD LRLIIAMTVC IVLLILIVLL RAIVAPLYLI
910 920 930 940 950
GSVIVSYLAA LGIGVIVFQF LLGQEMHWSI PGLTFVILVA VGADYNMLLI
960 970 980 990 1000
SRLREEAVLG VRSGVIRTVA STGGVITAAG LIMAASMYGL VFASLGSVVQ
1010 1020 1030 1040 1050
GAFVLGTGLL LDTFLVRTVT VPAIAVLVGQ ANWWLPSSWR PATWWPLGRR
1060 1070 1080
RGRAQRTKRK PLLPKEEEEQ SPPDDDDLIG LWLHDGLRL
Length:1,089
Mass (Da):115,998
Last modified:July 10, 2007 - v1
Checksum:iE9F842026831060F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ75652.1.
RefSeqiWP_003899710.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ75652; ABQ75652; MRA_3863.
KEGGimra:MRA_3863.
PATRICi18148253. VBIMycTub106795_4304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ75652.1.
RefSeqiWP_003899710.1. NC_009525.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419947.MRA_3863.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ75652; ABQ75652; MRA_3863.
KEGGimra:MRA_3863.
PATRICi18148253. VBIMycTub106795_4304.

Phylogenomic databases

HOGENOMiHOG000043539.
KOiK06994.
OMAiRRGWITP.
OrthoDBiEOG6RVFRF.

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-3984-MONOMER.

Family and domain databases

InterProiIPR004869. MMPL_dom.
IPR000731. SSD.
[Graphical view]
PfamiPF03176. MMPL. 2 hits.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv."
    Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L., Wang H., Wang S., Zhao G., Zhang Y.
    PLoS ONE 3:E2375-E2375(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25177 / H37Ra.

Entry informationi

Entry nameiMMPL8_MYCTA
AccessioniPrimary (citable) accession number: A5U9F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

In strain H37Ra, the sulfolipid-1 (SL-1) is not synthesized.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.