A5U8B7 (GLMM_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	MRA_3482

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_0000301343
Sites
	Active site	102	1	Phosphoserine intermediate By similarity
	Metal binding	102	1	Magnesium; via phosphate group By similarity
	Metal binding	243	1	Magnesium By similarity
	Metal binding	245	1	Magnesium By similarity
	Metal binding	247	1	Magnesium By similarity
Amino acid modifications
	Modified residue	102	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5U8B7 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 1A796BAC81742A04	FASTA	448	45,873
	10 20 30 40 50 60 MGRLFGTDGV RGVANRELTA ELALALGAAA ARRLSRSGAP GRRVAVLGRD PRASGEMLEA 70 80 90 100 110 120 AVIAGLTSEG VDALRVGVLP TPAVAYLTGA YDADFGVMIS ASHNPMPDNG IKIFGPGGHK 130 140 150 160 170 180 LDDDTEDQIE DLVLGVSRGP GLRPAGAGIG RVIDAEDATE RYLRHVAKAA TARLDDLAVV 190 200 210 220 230 240 VDCAHGAASS AAPRAYRAAG ARVIAINAEP NGRNINDGCG STHLDPLRAA VLAHRADLGL 250 260 270 280 290 300 AHDGDADRCL AVDANGDLVD GDAIMVVLAL AMKEAGELAC NTLVATVMSN LGLHLAMRSA 310 320 330 340 350 360 GVTVRTTAVG DRYVLEELRA GDYSLGGEQS GHIVMPALGS TGDGIVTGLR LMTRMVQTGS 370 380 390 400 410 420 SLSDLASAMR TLPQVLINVE VVDKATAAAA PSVRTAVEQA AAELGDTGRI LLRPSGTEPM 430 440 IRVMVEAADE GVAQRLAATV ADAVSTAR

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ75267.1.
RefSeq	YP_001284829.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U8B7.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U8B7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000065907; EBMYCP00000064017; EBMYCG00000065902.
GeneID	5215364.
GenomeReviews	Gene locus MRA_3482 in contig CP000611_GR.
KEGG	mra:MRA_3482.
PATRIC	18147406. VBIMycTub106795_3888.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
GeneTree	EBGT00050000015909.
HOGENOM	HBG644964.
OMA	GVGSTHL.
ProtClustDB	PRK14318.
Enzyme and pathway databases
BioCyc	MTUB419947:MRA_3482-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_MYCTA

Accession

Primary (citable) accession number: A5U8B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program