A5U894 (GCP_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp

Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein

Gene names

Name:	gcp
Ordered Locus Names:	MRA_3459

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine By similarity. HAMAP MF_01445
Subcellular location	Cytoplasm Potential HAMAP MF_01445.
Sequence similarities	Belongs to the KAE1 / YgjD family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp HAMAP MF_01445		PRO_0000303435

Sequences

	Sequence		Length	Mass (Da)
	A5U894 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 032B3EB3862CB2A4	FASTA	344	35,091
	10 20 30 40 50 60 MTTVLGIETS CDETGVGIAR LDPDGTVTLL ADEVASSVDE HVRFGGVVPE IASRAHLEAL 70 80 90 100 110 120 GPAMRRALAA AGLKQPDIVA ATIGPGLAGA LLVGVAAAKA YSAAWGVPFY AVNHLGGHLA 130 140 150 160 170 180 ADVYEHGPLP ECVALLVSGG HTHLLHVRSL GEPIIELGST VDDAAGEAYD KVARLLGLGY 190 200 210 220 230 240 PGGKALDDLA RTGDRDAIVF PRGMSGPADD RYAFSFSGLK TAVARYVESH AADPGFRTAD 250 260 270 280 290 300 IAAGFQEAVA DVLTMKAVRA ATALGVSTLL IAGGVAANSR LRELATQRCG EAGRTLRIPS 310 320 330 340 PRLCTDNGAM IAAFAAQLVA AGAPPSPLDV PSDPGLPVMQ GQVR

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ75244.1.
RefSeq	YP_001284806.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U894.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U894.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000066916; EBMYCP00000065026; EBMYCG00000066911.
GeneID	5211738.
GenomeReviews	Gene locus MRA_3459 in contig CP000611_GR.
KEGG	mra:MRA_3459.
PATRIC	18147348. VBIMycTub106795_3859.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0533.
GeneTree	EBGT00050000017447.
HOGENOM	HBG304663.
OMA	PLYGVNH.
ProtClustDB	PRK09604.
Enzyme and pathway databases
BioCyc	MTUB419947:MRA_3459-MONOMER.
Family and domain databases
HAMAP	MF_01445. gcp. [Tree]
InterPro	IPR022450. Pept_M22_O-sialoglycopept. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
KO	K01409.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR03723. Bact_gcp. 1 hit. TIGR00329. Gcp_kae1. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_MYCTA

Accession

Primary (citable) accession number: A5U894

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program