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A5U866

- CMAS1_MYCTA

UniProt

A5U866 - CMAS1_MYCTA

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Protein

Cyclopropane mycolic acid synthase 1

Gene
cmaA1, cma1, MRA_3431
Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei269 – 2691 By similarity

GO - Molecular functioni

  1. cyclopropane-fatty-acyl-phospholipid synthase activity Source: UniProtKB

GO - Biological processi

  1. lipid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-3541-MONOMER.
UniPathwayiUPA00915.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclopropane mycolic acid synthase 1 (EC:2.1.1.79)
Short name:
CMAS
Alternative name(s):
Cyclopropane-fatty-acyl-phospholipid synthase
Short name:
CFA synthase
Short name:
Cyclopropane fatty acid synthase
Mycolic acid methyltransferase
Short name:
MA-MT
S-adenosylmethionine-dependent methyltransferase
Short name:
AdoMet-MT
Short name:
SAM-MT
Gene namesi
Name:cmaA1
Synonyms:cma1
Ordered Locus Names:MRA_3431
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001988: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Cyclopropane mycolic acid synthase 1PRO_0000300063Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi419947.MRA_3431.

Structurei

3D structure databases

ProteinModelPortaliA5U866.
SMRiA5U866. Positions 3-287.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 342S-adenosyl-L-methionine binding By similarity
Regioni68 – 769S-adenosyl-L-methionine binding By similarity
Regioni94 – 996S-adenosyl-L-methionine binding By similarity
Regioni123 – 1242S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Belongs to the CFA/CMAS family.

Phylogenomic databases

eggNOGiCOG2230.
HOGENOMiHOG000245191.
KOiK00574.
OMAiADVQAHY.
OrthoDBiEOG6BGNZP.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR003333. Mycolic_cyclopropane_synthase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF02353. CMAS. 1 hit.
[Graphical view]
PIRSFiPIRSF003085. CMAS. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

A5U866-1 [UniParc]FASTAAdd to Basket

« Hide

MPDELKPHFA NVQAHYDLSD DFFRLFLDPT QTYSCAYFER DDMTLQEAQI    50
AKIDLALGKL GLQPGMTLLD VGCGWGATMM RAVEKYDVNV VGLTLSKNQA 100
NHVQQLVANS ENLRSKRVLL AGWEQFDEPV DRIVSIGAFE HFGHERYDAF 150
FSLAHRLLPA DGVMLLHTIT GLHPKEIHER GLPMSFTFAR FLKFIVTEIF 200
PGGRLPSIPM VQECASANGF TVTRVQSLQP HYAKTLDLWS AALQANKGQA 250
IALQSEEVYE RYMKYLTGCA EMFRIGYIDV NQFTCQK 287
Length:287
Mass (Da):32,461
Last modified:July 10, 2007 - v1
Checksum:i7E254C15DF5FFF97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U27357 Genomic DNA. Translation: AAA75624.1.
CP000611 Genomic DNA. Translation: ABQ75216.1.
RefSeqiYP_001284778.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ75216; ABQ75216; MRA_3431.
GeneIDi5214660.
KEGGimra:MRA_3431.
PATRICi18147292. VBIMycTub106795_3831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U27357 Genomic DNA. Translation: AAA75624.1 .
CP000611 Genomic DNA. Translation: ABQ75216.1 .
RefSeqi YP_001284778.1. NC_009525.1.

3D structure databases

ProteinModelPortali A5U866.
SMRi A5U866. Positions 3-287.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419947.MRA_3431.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ75216 ; ABQ75216 ; MRA_3431 .
GeneIDi 5214660.
KEGGi mra:MRA_3431.
PATRICi 18147292. VBIMycTub106795_3831.

Phylogenomic databases

eggNOGi COG2230.
HOGENOMi HOG000245191.
KOi K00574.
OMAi ADVQAHY.
OrthoDBi EOG6BGNZP.

Enzyme and pathway databases

UniPathwayi UPA00915 .
BioCyci MTUB419947:GJ8N-3541-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR003333. Mycolic_cyclopropane_synthase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF02353. CMAS. 1 hit.
[Graphical view ]
PIRSFi PIRSF003085. CMAS. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis."
    Yuan Y., Lee R.E., Besra G.S., Belisle J.T., Barry C.E. III
    Proc. Natl. Acad. Sci. U.S.A. 92:6630-6634(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION AS A CYCLOPROPANE SYNTHASE, NOMENCLATURE.
  2. "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
    Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25177 / H37Ra.

Entry informationi

Entry nameiCMAS1_MYCTA
AccessioniPrimary (citable) accession number: A5U866
Secondary accession number(s): Q11195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 10, 2007
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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