A5U844 (A5U844_MYCTA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902 EMBL ABQ75194.1
Ordered Locus Names:	MRA_3410

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	1079 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5U844 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 8F865C9D41A58D30	FASTA	1,079	116,484
	10 20 30 40 50 60 MERVLNGKPR HAGVPAFDAD GDVPRSRKRG AYQPPGRERV GSSVAYAELH AHSAYSFLDG 70 80 90 100 110 120 ASTPEELVEE AARLGLCALA LTDHDGLYGA VRFAEAAAEL DVRTVFGAEL SLGATARTER 130 140 150 160 170 180 PDPPGPHLLV LARGPEGYRR LSRQLAAAHL AGGEKGKPRY DFDALTEAAG GHWHILTGCR 190 200 210 220 230 240 KGHVRQALSQ GGPAAAQRAL ADLVDRFTPS RVSIELTHHG HPLDDERNAA LAGLAPRFGV 250 260 270 280 290 300 GIVATTGAHF ADPSRGRLAM AMAAIRARRS LDSAAGWLAP LGGAHLRSGE EMARLFAWCP 310 320 330 340 350 360 EAVTAAAELG ERCAFGLQLI APRLPPFDVP DGHTEDSWLR SLVMAGARER YGPPKSAPRA 370 380 390 400 410 420 YSQIEHELKV IAQLRFPGYF LVVHDITRFC RDNDILCQGR GSAANSAVCY ALGVTAVDPV 430 440 450 460 470 480 ANELLFERFL SPARDGPPDI DIDIESDQRE KVIQYVYHKY GRDYAAQVAN VITYRGRSAV 490 500 510 520 530 540 RDMARALGFS PGQQDAWSKQ VSHWTGQADD VDGIPEQVID LATQIRNLPR HLGIHSGGMV 550 560 570 580 590 600 ICDRPIADVC PVEWARMANR SVLQWDKDDC AAIGLVKFDL LGLGMLSALH YAKDLVAEHK 610 620 630 640 650 660 GIEVDLARLD LSEPAVYEML ARADSVGVFQ VESRAQMATL PRLKPRVFYD LVVEVALIRP 670 680 690 700 710 720 GPIQGGSVHP YIRRRNGVDP VIYEHPSMAP ALRKTLGVPL FQEQLMQLAV DCAGFSAAEA 730 740 750 760 770 780 DQLRRAMGSK RSTERMRRLR GRFYDGMRAL HGAPDEVIDR IYEKLEAFAN FGFPESHALS 790 800 810 820 830 840 FASLVFYSAW FKLHHPAAFC AALLRAQPMG FYSPQSLVAD ARRHGVAVHG PCVNASLAHA 850 860 870 880 890 900 TCENAGTEVR LGLGAVRYLG AELAEKLVAE RTANGPFTSL PDLTSRVQLS VPQVEALATA 910 920 930 940 950 960 GALGCFGMSR REALWAAGAA ATGRPDRLPG VGSSSHIPAL PGMSELELAA ADVWATGVSP 970 980 990 1000 1010 1020 DSYPTQFLRA DLDAMGVLPA ERLGSVSDGD RVLIAGAVTH RQRPATAQGV TFINLEDETG 1030 1040 1050 1060 1070 MVNVLCTPGV WARHRKLAHT APALLIRGQV QNASGAITVV AERMGRLTLA VGARSRDFR

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ75194.1.
RefSeq	YP_001284756.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U844.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U844.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000068811; EBMYCP00000066921; EBMYCG00000068806.
GeneID	5212500.
GenomeReviews	Gene locus MRA_3410 in contig CP000611_GR.
KEGG	mra:MRA_3410.
PATRIC	18147245. VBIMycTub106795_3808.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
GeneTree	EBGT00050000016568.
HOGENOM	HBG734490.
OMA	EQPAIRL.
ProtClustDB	PRK05672.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5U844_MYCTA

Accession

Primary (citable) accession number: A5U844

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)