A5U6T2 (A5U6T2_MYCTA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ribonuclease III EMBL ABQ74732.1

Gene names

Name:	rncS EMBL ABQ74732.1
Ordered Locus Names:	MRA_2952

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity. SAAS SAAS011907
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. SAAS SAAS011907
Subcellular location	Cytoplasm By similarity SAAS SAAS011907.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. SAAS SAAS011907 Contains 1 RNase III domain. SAAS SAAS011907

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS011907
Ligand	RNA-binding SAAS SAAS011907
Molecular function	Endonuclease SAAS SAAS011907 Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro rRNA catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5U6T2 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 64C8636742F161DC	FASTA	240	25,399
	10 20 30 40 50 60 MIRSRQPLLD ALGVDLPDEL LSLALTHRSY AYENGGLPTN ERLEFLGDAV LGLTITDALF 70 80 90 100 110 120 HRHPDRSEGD LAKLRASVVN TQALADVARR LCAEGLGVHV LLGRGEANTG GADKSSILAD 130 140 150 160 170 180 GMESLLGAIY LQHGMEKARE VILRLFGPLL DAAPTLGAGL DWKTSLQELT AARGLGAPSY 190 200 210 220 230 240 LVTSTGPDHD KEFTAVVVVM DSEYGSGVGR SKKEAEQKAA AAAWKALEVL DNAMPGKTSA

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ74732.1.
RefSeq	YP_001284294.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U6T2.
SMR	A5U6T2. Positions 2-155.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U6T2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000068444; EBMYCP00000066554; EBMYCG00000068439.
GeneID	5212661.
GenomeReviews	Gene locus MRA_2952 in contig CP000611_GR.
KEGG	mra:MRA_2952.
PATRIC	18146227. VBIMycTub106795_3302.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0571.
GeneTree	EBGT00050000017732.
HOGENOM	HBG744556.
OMA	ALTHKSF.
ProtClustDB	PRK00102.
Family and domain databases
HAMAP	MF_00104. RNase_III. [Tree]
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
KO	K03685.
PANTHER	PTHR11207. PTHR11207. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
SUPFAM	SSF69065. RNase_III. 1 hit.
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5U6T2_MYCTA

Accession

Primary (citable) accession number: A5U6T2

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)