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Protein

Ribonuclease HII

Gene

rnhB

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39Divalent metal cationUniRule annotation1
Metal bindingi40Divalent metal cationUniRule annotation1
Metal bindingi133Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:MRA_2927
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000311681 – 264Ribonuclease HIIAdd BLAST264

Interactioni

Protein-protein interaction databases

STRINGi419947.MtubH3_010100016501

Structurei

3D structure databases

ProteinModelPortaliA5U6Q7
SMRiA5U6Q7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UH2 Bacteria
COG0164 LUCA
HOGENOMiHOG000100288
KOiK03470
OMAiNILHASM

Family and domain databases

CDDicd07182 RNase_HII_bacteria_HII_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00052_B RNase_HII_B, 1 hit
InterProiView protein in InterPro
IPR022898 RNase_HII
IPR001352 RNase_HII/HIII
IPR024567 RNase_HII/HIII_dom
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10954 PTHR10954, 1 hit
PTHR10954:SF18 PTHR10954:SF18, 1 hit
PfamiView protein in Pfam
PF01351 RNase_HII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

A5U6Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTWPPRTV IRKSGGLRGM RTLESALHRG GLGPVAGVDE VGRGACAGPL
60 70 80 90 100
VVAACVLGPG RIASLAALDD SKKLSEQARE KLFPLICRYA VAYHVVFIPS
110 120 130 140 150
AEVDRRGVHV ANIEGMRRAV AGLAVRPGYV LSDGFRVPGL PMPSLPVIGG
160 170 180 190 200
DAAAACIAAA SVLAKVSRDR VMVALDADHP GYGFAEHKGY STPAHSRALA
210 220 230 240 250
RLGPCPQHRY SFINVRRVAS GSNTAEVADG QPDPRDGTAQ TGEGRWSKSS
260
HPATMRATGR AQGT
Length:264
Mass (Da):27,646
Last modified:July 10, 2007 - v1
Checksum:i786F0E790188279F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA Translation: ABQ74707.1
RefSeqiWP_003414713.1, NZ_CP016972.1

Genome annotation databases

EnsemblBacteriaiABQ74707; ABQ74707; MRA_2927
KEGGimra:MRA_2927

Similar proteinsi

Entry informationi

Entry nameiRNH2_MYCTA
AccessioniPrimary (citable) accession number: A5U6Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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