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Protein

Elongation factor Ts

Gene

tsf

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-3014-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TsUniRule annotation
Short name:
EF-TsUniRule annotation
Gene namesi
Name:tsfUniRule annotation
Ordered Locus Names:MRA_2914
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Elongation factor TsPRO_1000006132Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi419947.MtubH3_010100016431.

Structurei

3D structure databases

ProteinModelPortaliA5U6P4.
SMRiA5U6P4. Positions 5-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 794Involved in Mg(2+) ion dislocation from EF-TuUniRule annotation

Sequence similaritiesi

Belongs to the EF-Ts family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0264. LUCA.
HOGENOMiHOG000220986.
KOiK02357.
OMAiFIMEPKK.
OrthoDBiEOG66B42N.

Family and domain databases

Gene3Di3.30.479.20. 3 hits.
HAMAPiMF_00050. EF_Ts.
InterProiIPR001816. Transl_elong_EFTs/EF1B.
IPR014039. Transl_elong_EFTs/EF1B_dimer.
IPR018101. Transl_elong_Ts_CS.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR11741. PTHR11741. 1 hit.
PfamiPF00889. EF_TS. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54713. SSF54713. 2 hits.
TIGRFAMsiTIGR00116. tsf. 1 hit.
PROSITEiPS01126. EF_TS_1. 1 hit.
PS01127. EF_TS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5U6P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANFTAADVK RLRELTGAGM LACKNALAET DGDFDKAVEA LRIKGAKDVG
60 70 80 90 100
KRAERATAEG LVAAKDGALI ELNCETDFVA KNAEFQTLAD QVVAAAAAAK
110 120 130 140 150
PADVDALKGA SIGDKTVEQA IAELSAKIGE KLELRRVAIF DGTVEAYLHR
160 170 180 190 200
RSADLPPAVG VLVEYRGDDA AAAHAVALQI AALRARYLSR DDVPEDIVAS
210 220 230 240 250
ERRIAEETAR AEGKPEQALP KIVEGRLNGF FKDAVLLEQA SVSDNKKTVK
260 270
ALLDVAGVTV TRFVRFEVGQ A
Length:271
Mass (Da):28,755
Last modified:July 10, 2007 - v1
Checksum:i23064C8C2D95B0A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ74694.1.
RefSeqiWP_003899527.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ74694; ABQ74694; MRA_2914.
KEGGimra:MRA_2914.
PATRICi18146147. VBIMycTub106795_3262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ74694.1.
RefSeqiWP_003899527.1. NC_009525.1.

3D structure databases

ProteinModelPortaliA5U6P4.
SMRiA5U6P4. Positions 5-271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419947.MtubH3_010100016431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ74694; ABQ74694; MRA_2914.
KEGGimra:MRA_2914.
PATRICi18146147. VBIMycTub106795_3262.

Phylogenomic databases

eggNOGiCOG0264. LUCA.
HOGENOMiHOG000220986.
KOiK02357.
OMAiFIMEPKK.
OrthoDBiEOG66B42N.

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-3014-MONOMER.

Family and domain databases

Gene3Di3.30.479.20. 3 hits.
HAMAPiMF_00050. EF_Ts.
InterProiIPR001816. Transl_elong_EFTs/EF1B.
IPR014039. Transl_elong_EFTs/EF1B_dimer.
IPR018101. Transl_elong_Ts_CS.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR11741. PTHR11741. 1 hit.
PfamiPF00889. EF_TS. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54713. SSF54713. 2 hits.
TIGRFAMsiTIGR00116. tsf. 1 hit.
PROSITEiPS01126. EF_TS_1. 1 hit.
PS01127. EF_TS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv."
    Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L., Wang H., Wang S., Zhao G., Zhang Y.
    PLoS ONE 3:E2375-E2375(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25177 / H37Ra.

Entry informationi

Entry nameiEFTS_MYCTA
AccessioniPrimary (citable) accession number: A5U6P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.