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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:MRA_2875
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000238081 – 493Probable malate:quinone oxidoreductaseAdd BLAST493

Proteomic databases

PRIDEiA5U6K4.

Interactioni

Protein-protein interaction databases

STRINGi419947.MtubH3_010100000668.

Structurei

3D structure databases

ProteinModelPortaliA5U6K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00212. MQO. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR006231. MQO.
PfamiView protein in Pfam
PF06039. Mqo. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

A5U6K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLARTDVV LIGAGIMSAT LGVLLRRLEP NWSITLIERL DAVAAESSGP
60 70 80 90 100
WNNAGTGHSA LCEMNYTPEM PDGSIDITKA VRVNEQFQVT RQFWAYAAEN
110 120 130 140 150
GILTDVRSFL NPVPHVSFVH GSRGVEYLRR RQKALAGNPL FAGTEFIESP
160 170 180 190 200
DEFARRLPFM AAKRAFSEPV ALNWAADGTD VDFGALAKQL IGYCVQNGTT
210 220 230 240 250
ALFGHEVRNL SRQSDGSWTV TMCNRRTGEK RKLNTKFVFV GAGGDTLPVL
260 270 280 290 300
QKSGIKEVKG FAGFPIGGRF LRAGNPALTA SHRAKVYGFP APGAPPLGAL
310 320 330 340 350
HLDLRFVNGK SWLVFGPYAG WSPKFLKHGQ ISDLPRSIRP DNLLSVLGVG
360 370 380 390 400
LTERRLLNYL ISQLRLSEPE RVSALREFAP SAIDSDWELT IAGQRVQVIR
410 420 430 440 450
RDERNGGVLE FGTTVIGDAD GSIAGLLGGS PGASTAVAIM LDVLQKCFAN
460 470 480 490
RYQSWLPTLK EMVPSLGVQL SNEPALFDEV WSWSTKALKL GAA
Length:493
Mass (Da):53,595
Last modified:July 10, 2007 - v1
Checksum:iC3B4C469FF4F285F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ74654.1.
RefSeqiWP_003414545.1. NZ_CP016972.1.

Genome annotation databases

EnsemblBacteriaiABQ74654; ABQ74654; MRA_2875.
KEGGimra:MRA_2875.

Similar proteinsi

Entry informationi

Entry nameiMQO_MYCTA
AccessioniPrimary (citable) accession number: A5U6K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families