Reviewed, UniProtKB/Swiss-Prot A5U6K4 (MQO_MYCTA)

Names and origin

Protein names

Recommended name:
    Probable malate:quinone oxidoreductase
    EC=1.1.99.16
Alternative name(s):
    Malate dehydrogenase [acceptor]
    MQO

Gene names

Name:	mqo
Ordered Locus Names:	MRA_2875

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-malate + acceptor = oxaloacetate + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	malate dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Probable malate:quinone oxidoreductase		PRO_1000023808

Sequences

	Sequence		Length	Mass (Da)
	A5U6K4-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: C3B4C469FF4F285F	FASTA	493	53,595
	10 20 30 40 50 60 MSDLARTDVV LIGAGIMSAT LGVLLRRLEP NWSITLIERL DAVAAESSGP WNNAGTGHSA 70 80 90 100 110 120 LCEMNYTPEM PDGSIDITKA VRVNEQFQVT RQFWAYAAEN GILTDVRSFL NPVPHVSFVH 130 140 150 160 170 180 GSRGVEYLRR RQKALAGNPL FAGTEFIESP DEFARRLPFM AAKRAFSEPV ALNWAADGTD 190 200 210 220 230 240 VDFGALAKQL IGYCVQNGTT ALFGHEVRNL SRQSDGSWTV TMCNRRTGEK RKLNTKFVFV 250 260 270 280 290 300 GAGGDTLPVL QKSGIKEVKG FAGFPIGGRF LRAGNPALTA SHRAKVYGFP APGAPPLGAL 310 320 330 340 350 360 HLDLRFVNGK SWLVFGPYAG WSPKFLKHGQ ISDLPRSIRP DNLLSVLGVG LTERRLLNYL 370 380 390 400 410 420 ISQLRLSEPE RVSALREFAP SAIDSDWELT IAGQRVQVIR RDERNGGVLE FGTTVIGDAD 430 440 450 460 470 480 GSIAGLLGGS PGASTAVAIM LDVLQKCFAN RYQSWLPTLK EMVPSLGVQL SNEPALFDEV 490 WSWSTKALKL GAA

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000611 Genomic DNA. Translation: ABQ74654.1.
RefSeq	YP_001284216.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5212407.
GenomeReviews	Gene locus MRA_2875 in contig CP000611_GR.
KEGG	mra:MRA_2875.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00212. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO_MYCTA

Accession

Primary (citable) accession number: A5U6K4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	November 4, 2008
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)