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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28GTPUniRule annotation1
Binding sitei75GTPUniRule annotation1
Metal bindingi107MagnesiumUniRule annotation1
Binding sitei107GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 18GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:MRA_2479
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000191251 – 201Probable molybdenum cofactor guanylyltransferaseAdd BLAST201

Proteomic databases

PRIDEiA5U5E9

Interactioni

Protein-protein interaction databases

STRINGi419947.MtubH3_010100017830

Structurei

3D structure databases

ProteinModelPortaliA5U5E9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41080AZ Bacteria
COG0746 LUCA
HOGENOMiHOG000280425
KOiK03752
OMAiIFVMAAP

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

A5U5E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELAPDTVP LAGVVLAGGE SRRMGRDKAT LPLPGGTTTL VEHMVGILGQ
60 70 80 90 100
RCAPVFVMAA PGQPLPTLPV PVLRDELPGL GPLPATGRGL RAAAEAGVRL
110 120 130 140 150
AFVCAVDMPY LTVELIEDLA RRAVQTDAEV VLPWDGRNHY LAAVYRTDLA
160 170 180 190 200
DRVDTLVGAG ERKMSALVDA SDALRIVMAD SRPLTNVNSA AGLHAPMQPG

R
Length:201
Mass (Da):21,084
Last modified:July 10, 2007 - v1
Checksum:iD11A81501BBFEC72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA Translation: ABQ74249.1
RefSeqiWP_003412618.1, NZ_CP016972.1

Genome annotation databases

EnsemblBacteriaiABQ74249; ABQ74249; MRA_2479
KEGGimra:MRA_2479

Similar proteinsi

Entry informationi

Entry nameiMOBA_MYCTA
AccessioniPrimary (citable) accession number: A5U5E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health