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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281GTPUniRule annotation
Binding sitei75 – 751GTPUniRule annotation
Metal bindingi107 – 1071MagnesiumUniRule annotation
Binding sitei107 – 1071GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 183GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-2560-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:MRA_2479
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Probable molybdenum cofactor guanylyltransferasePRO_1000019125Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi419947.MtubH3_010100017830.

Structurei

3D structure databases

ProteinModelPortaliA5U5E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41080AZ. Bacteria.
COG0746. LUCA.
HOGENOMiHOG000280425.
KOiK03752.
OMAiRSHYLAA.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiIPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

A5U5E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELAPDTVP LAGVVLAGGE SRRMGRDKAT LPLPGGTTTL VEHMVGILGQ
60 70 80 90 100
RCAPVFVMAA PGQPLPTLPV PVLRDELPGL GPLPATGRGL RAAAEAGVRL
110 120 130 140 150
AFVCAVDMPY LTVELIEDLA RRAVQTDAEV VLPWDGRNHY LAAVYRTDLA
160 170 180 190 200
DRVDTLVGAG ERKMSALVDA SDALRIVMAD SRPLTNVNSA AGLHAPMQPG

R
Length:201
Mass (Da):21,084
Last modified:July 10, 2007 - v1
Checksum:iD11A81501BBFEC72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ74249.1.
RefSeqiWP_003412618.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ74249; ABQ74249; MRA_2479.
KEGGimra:MRA_2479.
PATRICi18145184. VBIMycTub106795_2790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ74249.1.
RefSeqiWP_003412618.1. NC_009525.1.

3D structure databases

ProteinModelPortaliA5U5E9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419947.MtubH3_010100017830.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ74249; ABQ74249; MRA_2479.
KEGGimra:MRA_2479.
PATRICi18145184. VBIMycTub106795_2790.

Phylogenomic databases

eggNOGiENOG41080AZ. Bacteria.
COG0746. LUCA.
HOGENOMiHOG000280425.
KOiK03752.
OMAiRSHYLAA.

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-2560-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiIPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOBA_MYCTA
AccessioniPrimary (citable) accession number: A5U5E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.