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A5U4S3 (A5U4S3_MYCTA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Name:aceE EMBL ABQ74023.1
Ordered Locus Names:MRA_2261
OrganismMycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]
Taxonomic identifier419947 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length901 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
A5U4S3 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: F7910AA5722539BF

FASTA901100,217
        10         20         30         40         50         60 
MASYLPDIDP EETSEWLESF DTLLQRCGPS RARYLMLRLL ERAGEQRVAI PALTSTDYVN 

        70         80         90        100        110        120 
TIPTELEPWF PGDEDVERRY RAWIRWNAAI MVHRAQRPGV GVGGHISTYA SSAALYEVGF 

       130        140        150        160        170        180 
NHFFRGKSHP GGGDQVFIQG HASPGIYARA FLEGRLTAEQ LDGFRQEHSH VGGGLPSYPH 

       190        200        210        220        230        240 
PRLMPDFWEF PTVSMGLGPL NAIYQARFNH YLHDRGIKDT SDQHVWCFLG DGEMDEPESR 

       250        260        270        280        290        300 
GLAHVGALEG LDNLTFVINC NLQRLDGPVR GNGKIIQELE SFFRGAGWNV IKVVWGREWD 

       310        320        330        340        350        360 
ALLHADRDGA LVNLMNTTPD GDYQTYKAND GGYVRDHFFG RDPRTKALVE NMSDQDIWNL 

       370        380        390        400        410        420 
KRGGHDYRKV YAAYRAAVDH KGQPTVILAK TIKGYALGKH FEGRNATHQM KKLTLEDLKE 

       430        440        450        460        470        480 
FRDTQRIPVS DAQLEENPYL PPYYHPGLNA PEIRYMLDRR RALGGFVPER RTKSKALTLP 

       490        500        510        520        530        540 
GRDIYAPLKK GSGHQEVATT MATVRTFKEV LRDKQIGPRI VPIIPDEART FGMDSWFPSL 

       550        560        570        580        590        600 
KIYNRNGQLY TAVDADLMLA YKESEVGQIL HEGINEAGSV GSFIAAGTSY ATHNEPMIPI 

       610        620        630        640        650        660 
YIFYSMFGFQ RTGDSFWAAA DQMARGFVLG ATAGRTTLTG EGLQHADGHS LLLAATNPAV 

       670        680        690        700        710        720 
VAYDPAFAYE IAYIVESGLA RMCGENPENI FFYITVYNEP YVQPPEPENF DPEGVLRGIY 

       730        740        750        760        770        780 
RYHAATEQRT NKAQILASGV AMPAALRAAQ MLAAEWDVAA DVWSVTSWGE LNRDGVAIET 

       790        800        810        820        830        840 
EKLRHPDRPA GVPYVTRALE NARGPVIAVS DWMRAVPEQI RPWVPGTYLT LGTDGFGFSD 

       850        860        870        880        890        900 
TRPAARRYFN TDAESQVVAV LEALAGDGEI DPSVPVAAAR QYRIDDVAAA PEQTTDPGPG 


A

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References

[1]"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000611 Genomic DNA. Translation: ABQ74023.1.
RefSeqYP_001283585.1. NC_009525.1.

3D structure databases

ProteinModelPortalA5U4S3.
SMRA5U4S3. Positions 56-891.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5U4S3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000067315; EBMYCP00000065425; EBMYCG00000067310.
GeneID5213385.
GenomeReviewsGene locus MRA_2261 in contig CP000611_GR.
KEGGmra:MRA_2261.
PATRIC18144658. VBIMycTub106795_2529.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2609.
GeneTreeEBGT00050000016271.
HOGENOMHBG289271.
OMAFRQEKSH.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5U4S3_MYCTA
AccessionPrimary (citable) accession number: A5U4S3
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info