ID   A5U4J0_MYCTA            Unreviewed;       679 AA.
AC   A5U4J0;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Penicillin-binding membrane protein PbpB {ECO:0000313|EMBL:ABQ73940.1};
GN   Name=pbpB {ECO:0000313|EMBL:ABQ73940.1};
GN   OrderedLocusNames=MRA_2178 {ECO:0000313|EMBL:ABQ73940.1};
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947 {ECO:0000313|EMBL:ABQ73940.1, ECO:0000313|Proteomes:UP000001988};
RN   [1] {ECO:0000313|EMBL:ABQ73940.1, ECO:0000313|Proteomes:UP000001988}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra {ECO:0000313|Proteomes:UP000001988};
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000611; ABQ73940.1; -; Genomic_DNA.
DR   RefSeq; WP_003411214.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U4J0; -.
DR   SMR; A5U4J0; -.
DR   KEGG; mra:MRA_2178; -.
DR   eggNOG; COG0768; Bacteria.
DR   HOGENOM; CLU_009289_6_5_11; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001988};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        93..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          131..295
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          339..654
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   679 AA;  72537 MW;  3FE57B17A4D265C4 CRC64;
     MSRAAPRRAS QSQSTRPARG LRRPPGAQEV GQRKRPGKTQ KARQAQEATK SRPATRSDVA
     PAGRSTRARR TRQVVDVGTR GASFVFRHRT GNAVILVLML VAATQLFFLQ VSHAAGLRAQ
     AAGQLKVTDV QPAARGSIVD RNNDRLAFTI EARALTFQPK RIRRQLEEAR KKTSAAPDPQ
     QRLRDIAQEV AGKLNNKPDA AAVLKKLQSD ETFVYLARAV DPAVASAICA KYPEVGAERQ
     DLRQYPGGSL AANVVGGIDW DGHGLLGLED SLDAVLAGTD GSVTYDRGSD GVVIPGSYRN
     RHKAVHGSTV VLTLDNDIQF YVQQQVQQAK NLSGAHNVSA VVLDAKTGEV LAMANDNTFD
     PSQDIGRQGD KQLGNPAVSS PFEPGSVNKI VAASAVIEHG LSSPDEVLQV PGSIQMGGVT
     VHDAWEHGVM PYTTTGVFGK SSNVGTLMLS QRVGPERYYD MLRKFGLGQR TGVGLPGESA
     GLVPPIDQWS GSTFANLPIG QGLSMTLLQM TGMYQAIAND GVRVPPRIIK ATVAPDGSRT
     EEPRPDDIRV VSAQTAQTVR QMLRAVVQRD PMGYQQGTGP TAGVPGYQMA GKTGTAQQIN
     PGCGCYFDDV YWITFAGIAT ADNPRYVIGI MLDNPARNSD GAPGHSAAPL FHNIAGWLMQ
     RENVPLSPDP GPPLVLQAT
//