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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-2237-MONOMER.
UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:MRA_2168
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_1000002671Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi419947.MRA_2168.

Structurei

3D structure databases

ProteinModelPortaliA5U4I0.
SMRiA5U4I0. Positions 38-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0707. LUCA.
HOGENOMiHOG000218323.
KOiK02563.
OMAiEQNALPG.
OrthoDBiEOG61VZFD.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

A5U4I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDTVSQPAG GRGATAPRPA DAASPSCGSS PSADSVSVVL AGGGTAGHVE
60 70 80 90 100
PAMAVADALV ALDPRVRITA LGTLRGLETR LVPQRGYHLE LITAVPMPRK
110 120 130 140 150
PGGDLARLPS RVWRAVREAR DVLDDVDADV VVGFGGYVAL PAYLAARGLP
160 170 180 190 200
LPPRRRRRIP VVIHEANARA GLANRVGAHT ADRVLSAVPD SGLRRAEVVG
210 220 230 240 250
VPVRASIAAL DRAVLRAEAR AHFGFPDDAR VLLVFGGSQG AVSLNRAVSG
260 270 280 290 300
AAADLAAAGV CVLHAHGPQN VLELRRRAQG DPPYVAVPYL DRMELAYAAA
310 320 330 340 350
DLVICRAGAM TVAEVSAVGL PAIYVPLPIG NGEQRLNALP VVNAGGGMVV
360 370 380 390 400
ADAALTPELV ARQVAGLLTD PARLAAMTAA AARVGHRDAA GQVARAALAV
410
ATGAGARTTT
Length:410
Mass (Da):41,860
Last modified:July 10, 2007 - v1
Checksum:i96902AFE356FC30B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ73930.1.
RefSeqiWP_003899190.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ73930; ABQ73930; MRA_2168.
KEGGimra:MRA_2168.
PATRICi18144463. VBIMycTub106795_2433.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ73930.1.
RefSeqiWP_003899190.1. NC_009525.1.

3D structure databases

ProteinModelPortaliA5U4I0.
SMRiA5U4I0. Positions 38-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419947.MRA_2168.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ73930; ABQ73930; MRA_2168.
KEGGimra:MRA_2168.
PATRICi18144463. VBIMycTub106795_2433.

Phylogenomic databases

eggNOGiCOG0707. LUCA.
HOGENOMiHOG000218323.
KOiK02563.
OMAiEQNALPG.
OrthoDBiEOG61VZFD.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciMTUB419947:GJ8N-2237-MONOMER.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv."
    Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L., Wang H., Wang S., Zhao G., Zhang Y.
    PLoS ONE 3:E2375-E2375(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25177 / H37Ra.

Entry informationi

Entry nameiMURG_MYCTA
AccessioniPrimary (citable) accession number: A5U4I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: November 11, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.