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A5U493

- BLAC_MYCTA

UniProt

A5U493 - BLAC_MYCTA

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Protein

Beta-lactamase

Gene
blaA, blaC, MRA_2082
Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-2149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:blaA
Synonyms:blaC
Ordered Locus Names:MRA_2082
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001988: Chromosome

Subcellular locationi

Cell membrane; Lipid-anchor Reviewed prediction

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 307284Beta-lactamasePRO_0000300061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi24 – 241N-palmitoyl cysteine Reviewed prediction
Lipidationi24 – 241S-diacylglycerol cysteine Reviewed prediction

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi419947.MRA_2082.

Structurei

Secondary structure

1
307
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi44 – 5411
Beta strandi58 – 636
Beta strandi72 – 754
Helixi83 – 864
Helixi87 – 9711
Helixi100 – 1045
Helixi111 – 1133
Helixi121 – 1233
Turni125 – 1273
Helixi131 – 14010
Helixi144 – 15411
Helixi158 – 1603
Helixi161 – 17010
Helixi184 – 1863
Helixi199 – 21012
Beta strandi212 – 2154
Helixi217 – 22812
Turni234 – 2363
Helixi237 – 2404
Beta strandi245 – 25410
Turni255 – 2573
Beta strandi258 – 2669
Beta strandi272 – 2809
Helixi282 – 2843
Helixi292 – 30615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DWZX-ray1.80A43-307[»]
ProteinModelPortaliA5U493.
SMRiA5U493. Positions 43-307.

Miscellaneous databases

EvolutionaryTraceiA5U493.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni250 – 2523Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2367.
HOGENOMiHOG000201073.
KOiK17836.
OMAiMKLIGGP.
OrthoDBiEOG6K9QFS.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5U493-1 [UniParc]FASTAAdd to Basket

« Hide

MRNRGFGRRE LLVAMAMLVS VTGCARHASG ARPASTTLPA GADLADRFAE    50
LERRYDARLG VYVPATGTTA AIEYRADERF AFCSTFKAPL VAAVLHQNPL 100
THLDKLITYT SDDIRSISPV AQQHVQTGMT IGQLCDAAIR YSDGTAANLL 150
LADLGGPGGG TAAFTGYLRS LGDTVSRLDA EEPELNRDPP GDERDTTTPH 200
AIALVLQQLV LGNALPPDKR ALLTDWMARN TTGAKRIRAG FPADWKVIDK 250
TGTGDYGRAN DIAVVWSPTG VPYVVAVMSD RAGGGYDAEP REALLAEAAT 300
CVAGVLA 307
Length:307
Mass (Da):32,568
Last modified:July 10, 2007 - v1
Checksum:i448CB2A0E05F4315
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67924 Genomic DNA. Translation: AAB07556.1.
CP000611 Genomic DNA. Translation: ABQ73843.1.
RefSeqiYP_001283405.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ73843; ABQ73843; MRA_2082.
GeneIDi5212563.
KEGGimra:MRA_2082.
PATRICi18144269. VBIMycTub106795_2337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67924 Genomic DNA. Translation: AAB07556.1 .
CP000611 Genomic DNA. Translation: ABQ73843.1 .
RefSeqi YP_001283405.1. NC_009525.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3DWZ X-ray 1.80 A 43-307 [» ]
ProteinModelPortali A5U493.
SMRi A5U493. Positions 43-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419947.MRA_2082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ73843 ; ABQ73843 ; MRA_2082 .
GeneIDi 5212563.
KEGGi mra:MRA_2082.
PATRICi 18144269. VBIMycTub106795_2337.

Phylogenomic databases

eggNOGi COG2367.
HOGENOMi HOG000201073.
KOi K17836.
OMAi MKLIGGP.
OrthoDBi EOG6K9QFS.

Enzyme and pathway databases

BioCyci MTUB419947:GJ8N-2149-MONOMER.

Miscellaneous databases

EvolutionaryTracei A5U493.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of a class A beta-lactamase from Mycobacterium tuberculosis H37Ra."
    Hackbarth C.J., Unsal I., Chambers H.F.
    Antimicrob. Agents Chemother. 41:1182-1185(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
    Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25177 / H37Ra.

Entry informationi

Entry nameiBLAC_MYCTA
AccessioniPrimary (citable) accession number: A5U493
Secondary accession number(s): P0A5I6, Q10670
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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