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A5U3J9 (GCSP_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:MRA_1843
OrganismMycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]
Taxonomic identifier419947 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length941 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 941941Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045591

Amino acid modifications

Modified residue6921N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A5U3J9 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: BFFDE54EDA56B914

FASTA94199,511
        10         20         30         40         50         60 
MSDHSTFADR HIGLDSQAVA TMLAVIGVDS LDDLAVKAVP AGILDTLTDT GAAPGLDSLP 

        70         80         90        100        110        120 
PAASEAEALA ELRALADANT VAVSMIGQGY YDTHTPPVLL RNIIENPAWY TAYTPYQPEI 

       130        140        150        160        170        180 
SQGRLEALLN FQTLVTDLTG LEIANASMLD EGTAAAEAMT LMHRAARGPV KRVVVDADVF 

       190        200        210        220        230        240 
TQTAAVLATR AKPLGIEIVT ADLRAGLPDG EFFGVIAQLP GASGRITDWS ALVQQAHDRG 

       250        260        270        280        290        300 
ALVAVGADLL ALTLIAPPGE IGADVAFGTT QRFGVPMGFG GPHAGYLAVH AKHARQLPGR 

       310        320        330        340        350        360 
LVGVSVDSDG TPAYRLALQT REQHIRRDKA TSNICTAQVL LAVLAAMYAS YHGAGGLTAI 

       370        380        390        400        410        420 
ARRVHAHAEA IAGALGDALV HDKYFDTVLA RVPGRADEVL ARAKANGINL WRVDADHVSV 

       430        440        450        460        470        480 
ACDEATTDTH VAVVLDAFGV AAAAPAHTDI ATRTSEFLTH PAFTQYRTET SMMRYLRALA 

       490        500        510        520        530        540 
DKDIALDRSM IPLGSCTMKL NAAAEMESIT WPEFGRQHPF APASDTAGLR QLVADLQSWL 

       550        560        570        580        590        600 
VLITGYDAVS LQPNAGSQGE YAGLLAIHEY HASRGEPHRD ICLIPSSAHG TNAASAALAG 

       610        620        630        640        650        660 
MRVVVVDCHD NGDVDLDDLR AKVGEHAERL SALMITYPST HGVYEHDIAE ICAAVHDAGG 

       670        680        690        700        710        720 
QVYVDGANLN ALVGLARPGK FGGDVSHLNL HKTFCIPHGG GGPGVGPVAV RAHLAPFLPG 

       730        740        750        760        770        780 
HPFAPELPKG YPVSSAPYGS ASILPITWAY IRMMGAEGLR AASLTAITSA NYIARRLDEY 

       790        800        810        820        830        840 
YPVLYTGENG MVAHECILDL RGITKLTGIT VDDVAKRLAD YGFHAPTMSF PVAGTLMVEP 

       850        860        870        880        890        900 
TESESLAEVD AFCEAMIGIR AEIDKVGAGE WPVDDNPLRG APHTAQCLLA SDWDHPYTRE 

       910        920        930        940 
QAAYPLGTAF RPKVWPAVRR IDGAYGDRNL VCSCPPVEAF A 

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References

[1]"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000611 Genomic DNA. Translation: ABQ73599.1.
RefSeqYP_001283161.1. NC_009525.1.

3D structure databases

ProteinModelPortalA5U3J9.
SMRA5U3J9. Positions 6-934.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING419947.MRA_1843.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ73599; ABQ73599; MRA_1843.
GeneID5211850.
KEGGmra:MRA_1843.
PATRIC18143727. VBIMycTub106795_2065.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycMTUB419947:GJ8N-1905-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_MYCTA
AccessionPrimary (citable) accession number: A5U3J9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: March 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families