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A5U390 (GABD2_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative succinate-semialdehyde dehydrogenase [NADP+] 2
Short name=SSADH 2
Short name=SSDH 2
EC=1.2.1.79
Gene names
Name:gabD2
Ordered Locus Names:MRA_1741
OrganismMycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]
Taxonomic identifier419947 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. Although it has succinate semialdehyde dehydrogenase activity, is likely to act physiologically on a different aldehyde(s) By similarity.

Catalytic activity

Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Putative succinate-semialdehyde dehydrogenase [NADP+] 2
PRO_0000310712

Regions

Nucleotide binding157 – 1582NADP By similarity
Nucleotide binding181 – 1844NADP By similarity
Nucleotide binding232 – 2332NADP By similarity

Sites

Active site2541Proton acceptor By similarity
Active site2881Nucleophile By similarity
Binding site2551NADP; via carbonyl oxygen By similarity
Binding site3861NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
A5U390 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: E3AC9E895EB46270

FASTA51855,324
        10         20         30         40         50         60 
MPAPSAEVFD RLRNLAAIKD VAARPTRTID EVFTGKPLTT IPVGTAADVE AAFAEARAAQ 

        70         80         90        100        110        120 
TDWAKRPVIE RAAVIRRYRD LVIENREFLM DLLQAEAGKA RWAAQEEIVD LIANANYYAR 

       130        140        150        160        170        180 
VCVDLLKPRK AQPLLPGIGK TTVCYQPKGV VGVISPWNYP MTLTVSDSVP ALVAGNAVVL 

       190        200        210        220        230        240 
KPDSQTPYCA LACAELLYRA GLPRALYAIV PGPGSVVGTA ITDNCDYLMF TGSSATGSRL 

       250        260        270        280        290        300 
AEHAGRRLIG FSAELGGKNP MIVARGANLD KVAKAATRAC FSNAGQLCIS IERIYVEKDI 

       310        320        330        340        350        360 
AEEFTRKFGD AVRNMKLGTA YDFSVDMGSL ISEAQLKTVS GHVDDATAKG AKVIAGGKAR 

       370        380        390        400        410        420 
PDIGPLFYEP TVLTNVAPEM ECAANETFGP VVSIYPVADV DEAVEKANDT DYGLNASVWA 

       430        440        450        460        470        480 
GSTAEGQRIA ARLRSGTVNV DEGYAFAWGS LSAPMGGMGL SGVGRRHGPE GLLKYTESQT 

       490        500        510 
IATARVFNLD PPFGIPATVW QKSLLPIVRT VMKLPGRR

« Hide

References

[1]"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000611 Genomic DNA. Translation: ABQ73490.1.
RefSeqYP_001283052.1. NC_009525.1.

3D structure databases

ProteinModelPortalA5U390.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5U390.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000067870; EBMYCP00000065980; EBMYCG00000067865.
GeneID5211890.
GenomeReviewsGene locus MRA_1741 in contig CP000611_GR.
KEGGmra:MRA_1741.
PATRIC18143467. VBIMycTub106795_1934.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
GeneTreeEBGT00050000015660.
HOGENOMHBG752218.
OMAGPLVSIY.
ProtClustDBPRK09407.

Enzyme and pathway databases

BioCycMTUB419947:MRA_1741-MONOMER.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00135.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. False negative.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGABD2_MYCTA
AccessionPrimary (citable) accession number: A5U390
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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