A5U371 (KCY_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	MRA_1722

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Cytidylate kinase HAMAP MF_00238		PRO_1000048239
Regions
	Nucleotide binding	13 – 21	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5U371 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: D1E6BF0354D13AA3	FASTA	230	24,177
	10 20 30 40 50 60 MSRLSAAVVA IDGPAGTGKS SVSRRLAREL GARFLDTGAM YRIVTLAVLR AGADPSDIAA 70 80 90 100 110 120 VETIASTVQM SLGYDPDGDS CYLAGEDVSV EIRGDAVTRA VSAVSSVPAV RTRLVELQRT 130 140 150 160 170 180 MAEGPGSIVV EGRDIGTVVF PDAPVKIFLT ASAETRARRR NAQNVAAGLA DDYDGVLADV 190 200 210 220 230 RRRDHLDSTR AVSPLQAAGD AVIVDTSDMT EAEVVAHLLE LVTRRSEAVR

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ73471.1.
RefSeq	YP_001283033.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U371.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U371.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000066977; EBMYCP00000065087; EBMYCG00000066972.
GeneID	5215342.
GenomeReviews	Gene locus MRA_1722 in contig CP000611_GR.
KEGG	mra:MRA_1722.
PATRIC	18143423. VBIMycTub106795_1913.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0283.
GeneTree	EBGT00050000015811.
HOGENOM	HBG354377.
OMA	DIGTVIC.
ProtClustDB	PRK00023.
Enzyme and pathway databases
BioCyc	MTUB419947:MRA_1722-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_MYCTA

Accession

Primary (citable) accession number: A5U371

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program