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A5U316 (ARLY_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:MRA_1670
OrganismMycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]
Taxonomic identifier419947 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Argininosuccinate lyase HAMAP MF_00006
PRO_1000000510

Sequences

Sequence LengthMass (Da)Tools
A5U316 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 1844ED923D797ECE

FASTA47049,774
        10         20         30         40         50         60 
MSTNEGSLWG GRFAGGPSDA LAALSKSTHF DWVLAPYDLT ASRAHTMVLF RAGLLTEEQR 

        70         80         90        100        110        120 
DGLLAGLDSL AQDVADGSFG PLVTDEDVHA ALERGLIDRV GPDLGGRLRA GRSRNDQVAA 

       130        140        150        160        170        180 
LFRMWLRDAV RRVATGVLDV VGALAEQAAA HPSAIMPGKT HLQSAQPILL AHHLLAHAHP 

       190        200        210        220        230        240 
LLRDLDRIVD FDKRAAVSPY GSGALAGSSL GLDPDAIAAD LGFSAAADNS VDATAARDFA 

       250        260        270        280        290        300 
AEAAFVFAMI AVDLSRLAED IIVWSSTEFG YVTLHDSWST GSSIMPQKKN PDIAELARGK 

       310        320        330        340        350        360 
SGRLIGNLAG LLATLKAQPL AYNRDLQEDK EPVFDSVAQL ELLLPAMAGL VASLTFNVQR 

       370        380        390        400        410        420 
MAELAPAGYT LATDLAEWLV RQGVPFRSAH EAAGAAVRAA EQRGVGLQEL TDDELAAISP 

       430        440        450        460        470 
ELTPQVREVL TIEGSVSARD CRGGTAPGRV AEQLNAIGEA AERLRRQLVR

« Hide

References

[1]"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000611 Genomic DNA. Translation: ABQ73416.1.
RefSeqYP_001282978.1. NC_009525.1.

3D structure databases

ProteinModelPortalA5U316.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5U316.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000068134; EBMYCP00000066244; EBMYCG00000068129.
GeneID5215525.
GenomeReviewsGene locus MRA_1670 in contig CP000611_GR.
KEGGmra:MRA_1670.
PATRIC18143305. VBIMycTub106795_1854.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
GeneTreeEBGT00050000016253.
HOGENOMHBG539632.
OMAMPGRTHL.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycMTUB419947:MRA_1670-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_MYCTA
AccessionPrimary (citable) accession number: A5U316
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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