A5U309 (ARGC_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	MRA_1663

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000011022
Sites
	Active site	158	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5U309 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: E7E36B6FC1BAD5CC	FASTA	352	36,304
	10 20 30 40 50 60 MQNRQVANAT KVAVAGASGY AGGEILRLLL GHPAYADGRL RIGALTAATS AGSTLGEHHP 70 80 90 100 110 120 HLTPLAHRVV EPTEAAVLGG HDAVFLALPH GHSAVLAQQL SPETLIIDCG ADFRLTDAAV 130 140 150 160 170 180 WERFYGSSHA GSWPYGLPEL PGARDQLRGT RRIAVPGCYP TAALLALFPA LAADLIEPAV 190 200 210 220 230 240 TVVAVSGTSG AGRAATTDLL GAEVIGSARA YNIAGVHRHT PEIAQGLRAV TDRDVSVSFT 250 260 270 280 290 300 PVLIPASRGI LATCTARTRS PLSQLRAAYE KAYHAEPFIY LMPEGQLPRT GAVIGSNAAH 310 320 330 340 350 IAVAVDEDAQ TFVAIAAIDN LVKGTAGAAV QSMNLALGWP ETDGLSVVGV AP

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ73409.1.
RefSeq	YP_001282971.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U309.
SMR	A5U309. Positions 6-352.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U309.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000068820; EBMYCP00000066930; EBMYCG00000068815.
GeneID	5215198.
GenomeReviews	Gene locus MRA_1663 in contig CP000611_GR.
KEGG	mra:MRA_1663.
PATRIC	18143291. VBIMycTub106795_1847.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
GeneTree	EBGT00050000015828.
HOGENOM	HBG294213.
OMA	VCRIAVH.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	MTUB419947:MRA_1663-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_MYCTA

Accession

Primary (citable) accession number: A5U309

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program