A5U2W2 (HIS3_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	MRA_1616

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	115 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity HAMAP MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 115	115	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_1000063418

Sequences

	Sequence		Length	Mass (Da)
	A5U2W2 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 07519F1E5D4D6D83	FASTA	115	12,465
	10 20 30 40 50 60 MTLDPKIAAR LKRNADGLVT AVVQERGSGD VLMVAWMNDE ALARTLQTRE ATYYSRSRAE 70 80 90 100 110 QWVKGATSGH TQHVHSVRLD CDGDAVLLTV DQVGGACHTG DHSCFDAAVL LEPDD

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ73362.1.
RefSeq	YP_001282924.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U2W2.
SMR	A5U2W2. Positions 10-108.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U2W2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000066658; EBMYCP00000064768; EBMYCG00000066653.
GeneID	5215371.
GenomeReviews	Gene locus MRA_1616 in contig CP000611_GR.
KEGG	mra:MRA_1616.
PATRIC	18143185. VBIMycTub106795_1795.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0139.
GeneTree	EBGT00050000017128.
HOGENOM	HBG294308.
OMA	GACHVGY.
ProtClustDB	PRK00051.
Enzyme and pathway databases
BioCyc	MTUB419947:MRA_1616-MONOMER.
Family and domain databases
HAMAP	MF_01021. HisI. [Tree]
InterPro	IPR002496. PRib_AMP_CycHydrolase. [Graphical view]
KO	K01496.
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_MYCTA

Accession

Primary (citable) accession number: A5U2W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program