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A5U2V9

- HIS4_MYCTA

UniProt

A5U2V9 - HIS4_MYCTA

Protein

Phosphoribosyl isomerase A

Gene

priA

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Involved in both the histidine and tryptophan biosynthetic pathways.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei11 – 111Proton acceptorUniRule annotation
    Active sitei130 – 1301Proton donorUniRule annotation

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP
    2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP
    2. tryptophan biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Histidine biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciMTUB419947:GJ8N-1663-MONOMER.
    UniPathwayiUPA00031; UER00009.
    UPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl isomerase AUniRule annotation
    Alternative name(s):
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)
    N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
    Short name:
    PRAIUniRule annotation
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation
    Gene namesi
    Name:priAUniRule annotation
    Synonyms:hisAUniRule annotation
    Ordered Locus Names:MRA_1613
    OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
    Taxonomic identifieri419947 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001988: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Phosphoribosyl isomerase APRO_1000063221Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi419947.MRA_1613.

    Structurei

    3D structure databases

    ProteinModelPortaliA5U2V9.
    SMRiA5U2V9. Positions 2-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000224614.
    KOiK01814.
    K01817.
    OMAiQRDYGSD.
    OrthoDBiEOG6H1Q3W.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01014. HisA.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR010188. HisA_TrpF.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01919. hisA-trpF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5U2V9-1 [UniParc]FASTAAdd to Basket

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    MMPLILLPAV DVVEGRAVRL VQGKAGSQTE YGSAVDAALG WQRDGAEWIH    50
    LVDLDAAFGR GSNHELLAEV VGKLDVQVEL SGGIRDDESL AAALATGCAR 100
    VNVGTAALEN PQWCARVIGE HGDQVAVGLD VQIIDGEHRL RGRGWETDGG 150
    DLWDVLERLD SEGCSRFVVT DITKDGTLGG PNLDLLAGVA DRTDAPVIAS 200
    GGVSSLDDLR AIATLTHRGV EGAIVGKALY ARRFTLPQAL AAVRD 245
    Length:245
    Mass (Da):25,763
    Last modified:July 10, 2007 - v1
    Checksum:i906C2C40268C3257
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ73359.1.
    RefSeqiYP_001282921.1. NC_009525.1.

    Genome annotation databases

    EnsemblBacteriaiABQ73359; ABQ73359; MRA_1613.
    GeneIDi5211626.
    KEGGimra:MRA_1613.
    PATRICi18143179. VBIMycTub106795_1792.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ73359.1 .
    RefSeqi YP_001282921.1. NC_009525.1.

    3D structure databases

    ProteinModelPortali A5U2V9.
    SMRi A5U2V9. Positions 2-245.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 419947.MRA_1613.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ73359 ; ABQ73359 ; MRA_1613 .
    GeneIDi 5211626.
    KEGGi mra:MRA_1613.
    PATRICi 18143179. VBIMycTub106795_1792.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000224614.
    KOi K01814.
    K01817.
    OMAi QRDYGSD.
    OrthoDBi EOG6H1Q3W.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .
    UPA00035 ; UER00042 .
    BioCyci MTUB419947:GJ8N-1663-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01014. HisA.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR010188. HisA_TrpF.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01919. hisA-trpF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
      Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25177 / H37Ra.

    Entry informationi

    Entry nameiHIS4_MYCTA
    AccessioniPrimary (citable) accession number: A5U2V9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3