A5U2Q4 (A5U2Q4_MYCTA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DNA polymerase III subunit alpha DnaE1 EMBL ABQ73304.1

Gene names

Name:	dnaE1 EMBL ABQ73304.1
Ordered Locus Names:	MRA_1559

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	1184 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SAAS SAAS004013

Ontologies

Keywords
Biological process	DNA replication SAAS SAAS004013
Cellular component	Cytoplasm SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5U2Q4 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: A87AB7F0F2E08909	FASTA	1,184	129,323
	10 20 30 40 50 60 MSGSSAGSSF VHLHNHTEYS MLDGAAKITP MLAEVERLGM PAVGMTDHGN MFGASEFYNS 70 80 90 100 110 120 ATKAGIKPII GVEAYIAPGS RFDTRRILWG DPSQKADDVS GSGSYTHLTM MAENATGLRN 130 140 150 160 170 180 LFKLSSHASF EGQLSKWSRM DAELIAEHAE GIIITTGCPS GEVQTRLRLG QDREALEAAA 190 200 210 220 230 240 KWREIVGPDN YFLELMDHGL TIERRVRDGL LEIGRALNIP PLATNDCHYV TRDAAHNHEA 250 260 270 280 290 300 LLCVQTGKTL SDPNRFKFDG DGYYLKSAAE MRQIWDDEVP GACDSTLLIA ERVQSYADVW 310 320 330 340 350 360 TPRDRMPVFP VPDGHDQASW LRHEVDAGLR RRFPAGPPDG YRERAAYEID VICSKGFPSY 370 380 390 400 410 420 FLIVADLISY ARSAGIRVGP GRGSAAGSLV AYALGITDID PIPHGLLFER FLNPERTSMP 430 440 450 460 470 480 DIDIDFDDRR RGEMVRYAAD KWGHDRVAQV ITFGTIKTKA ALKDSARIHY GQPGFAIADR 490 500 510 520 530 540 ITKALPPAIM AKDIPLSGIT DPSHERYKEA AEVRGLIETD PDVRTIYQTA RGLEGLIRNA 550 560 570 580 590 600 GVHACAVIMS SEPLTEAIPL WKRPQDGAII TGWDYPACEA IGLLKMDFLG LRNLTIIGDA 610 620 630 640 650 660 IDNVRANRGI DLDLESVPLD DKATYELLGR GDTLGVFQLD GGPMRDLLRR MQPTGFEDVV 670 680 690 700 710 720 AVIALYRPGP MGMNAHNDYA DRKNNRQAIK PIHPELEEPL REILAETYGL IVYQEQIMRI 730 740 750 760 770 780 AQKVASYSLA RADILRKAMG KKKREVLEKE FEGFSDGMQA NGFSPAAIKA LWDTILPFAD 790 800 810 820 830 840 YAFNKSHAAG YGMVSYWTAY LKANYPAEYM AGLLTSVGDD KDKAAVYLAD CRKLGITVLP 850 860 870 880 890 900 PDVNESGLNF ASVGQDIRYG LGAVRNVGAN VVGSLLQTRN DKGKFTDFSD YLNKIDISAC 910 920 930 940 950 960 NKKVTESLIK AGAFDSLGHA RKGLFLVHSD AVDSVLGTKK AEALGQFDLF GSNDDGTGTA 970 980 990 1000 1010 1020 DPVFTIKVPD DEWEDKHKLA LEREMLGLYV SGHPLNGVAH LLAAQVDTAI PAILDGDVPN 1030 1040 1050 1060 1070 1080 DAQVRVGGIL ASVNRRVNKN GMPWASAQLE DLTGGIEVMF FPHTYSSYGA DIVDDAVVLV 1090 1100 1110 1120 1130 1140 NAKVAVRDDR IALIANDLTV PDFSNAEVER PLAVSLPTRQ CTFDKVSALK QVLARHPGTS 1150 1160 1170 1180 QVHLRLISGD RITTLALDQS LRVTPSPALM GDLKELLGPG CLGS

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ73304.1.
RefSeq	YP_001282866.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U2Q4.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U2Q4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000066124; EBMYCP00000064234; EBMYCG00000066119.
GeneID	5215290.
GenomeReviews	Gene locus MRA_1559 in contig CP000611_GR.
KEGG	mra:MRA_1559.
PATRIC	18143065. VBIMycTub106795_1734.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
GeneTree	EBGT00050000016568.
HOGENOM	HBG734490.
OMA	RVLQMPY.
ProtClustDB	PRK05673.
Family and domain databases
InterPro	IPR011708. DNA_pol3_alpha. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K02337.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5U2Q4_MYCTA

Accession

Primary (citable) accession number: A5U2Q4

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)