A5U2I8 (A5U2I8_MYCTA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] PIRNR PIRNR000094
EC=1.3.1.9 PIRNR PIRNR000094

Gene names

Name:	inhA EMBL ABQ73238.1
Ordered Locus Names:	MRA_1494

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH. PIRNR PIRNR000094
Pathway	Lipid metabolism; fatty acid biosynthesis. PIRNR PIRNR000094
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. PIRNR PIRNR000094

Ontologies

Keywords
Biological process	Fatty acid biosynthesis PIRNR PIRNR000094 Lipid synthesis
Ligand	NAD PIRNR PIRNR000094
Molecular function	Oxidoreductase PIRNR PIRNR000094
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	158	1	Proton acceptor By similarity PIRSR PIRSR000094-1

Sequences

	Sequence		Length	Mass (Da)
	A5U2I8 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: F161D6D6A631CA08	FASTA	269	28,528
	10 20 30 40 50 60 MTGLLDGKRI LVSGIITDSS IAFHIARVAQ EQGAQLVLTG FDRLRLIQRI TDRLPAKAPL 70 80 90 100 110 120 LELDVQNEEH LASLAGRVTE AIGAGNKLDG VVHSIGFMPQ TGMGINPFFD APYADVSKGI 130 140 150 160 170 180 HISAYSYASM AKALLPIMNP GGSIVGMDFD PSRAMPAYNW MTVAKSALES VNRFVAREAG 190 200 210 220 230 240 KYGVRSNLVA AGPIRTLAMS AIVGGALGEE AGAQIQLLEE GWDQRAPIGW NMKDATPVAK 250 260 TVCALLSDWL PATTGDIIYA DGGAHTQLL

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ73238.1.
RefSeq	YP_001282800.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U2I8.
SMR	A5U2I8. Positions 2-269.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U2I8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000065612; EBMYCP00000063722; EBMYCG00000065607.
GeneID	5215049.
GenomeReviews	Gene locus MRA_1494 in contig CP000611_GR.
KEGG	mra:MRA_1494.
PATRIC	18142921. VBIMycTub106795_1662.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0623.
GeneTree	EBGT00050000015205.
HOGENOM	HBG750976.
OMA	DCDVGSD.
ProtClustDB	PRK07889.
Family and domain databases
InterPro	IPR014358. Enoyl-ACP_Rdtase_NADH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K11611.
PIRSF	PIRSF000094. Enoyl-ACP_rdct. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5U2I8_MYCTA

Accession

Primary (citable) accession number: A5U2I8

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)