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A5U2D9

- PGK_MYCTA

UniProt

A5U2D9 - PGK_MYCTA

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401SubstrateUniRule annotation
    Binding sitei122 – 1221SubstrateUniRule annotation
    Binding sitei162 – 1621SubstrateUniRule annotation
    Binding sitei212 – 2121ATPUniRule annotation
    Binding sitei300 – 3001ATP; via carbonyl oxygenUniRule annotation
    Binding sitei331 – 3311ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi360 – 3634ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMTUB419947:GJ8N-1493-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:MRA_1445
    OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
    Taxonomic identifieri419947 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001988: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 412412Phosphoglycerate kinasePRO_1000009635Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi419947.MRA_1445.

    Structurei

    3D structure databases

    ProteinModelPortaliA5U2D9.
    SMRiA5U2D9. Positions 16-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingUniRule annotation
    Regioni63 – 664Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5U2D9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVANLKDLL AEGVSGRGVL VRSDLNVPLD EDGTITDAGR IIASAPTLKA    50
    LLDADAKVVV AAHLGRPKDG PDPTLSLAPV AVALGEQLGR HVQLAGDVVG 100
    ADALARAEGL TGGDILLLEN IRFDKRETSK NDDDRRALAK QLVELVGTGG 150
    VFVSDGFGVV HRKQASVYDI ATLLPHYAGT LVADEMRVLE QLTSSTQRPY 200
    AVVLGGSKVS DKLGVIESLA TKADSIVIGG GMCFTFLAAQ GFSVGTSLLE 250
    DDMIEVCRGL LETYHDVLRL PVDLVVTEKF AADSPPQTVD VGAVPNGLMG 300
    LDIGPGSIKR FSTLLSNAGT IFWNGPMGVF EFPAYAAGTR GVAEAIVAAT 350
    GKGAFSVVGG GDSAAAVRAM NIPEGAFSHI STGGGASLEY LEGKTLPGIE 400
    VLSREQPTGG VL 412
    Length:412
    Mass (Da):42,512
    Last modified:July 10, 2007 - v1
    Checksum:i0075CB4B607E65E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ73189.1.
    RefSeqiYP_001282751.1. NC_009525.1.

    Genome annotation databases

    EnsemblBacteriaiABQ73189; ABQ73189; MRA_1445.
    GeneIDi5211781.
    KEGGimra:MRA_1445.
    PATRICi18142811. VBIMycTub106795_1607.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ73189.1 .
    RefSeqi YP_001282751.1. NC_009525.1.

    3D structure databases

    ProteinModelPortali A5U2D9.
    SMRi A5U2D9. Positions 16-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 419947.MRA_1445.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ73189 ; ABQ73189 ; MRA_1445 .
    GeneIDi 5211781.
    KEGGi mra:MRA_1445.
    PATRICi 18142811. VBIMycTub106795_1607.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci MTUB419947:GJ8N-1493-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
      Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25177 / H37Ra.

    Entry informationi

    Entry nameiPGK_MYCTA
    AccessioniPrimary (citable) accession number: A5U2D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3