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A5U287

- PYRF_MYCTA

UniProt

A5U287 - PYRF_MYCTA

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Proton donorUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciMTUB419947:GJ8N-1441-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:MRA_1394
    OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
    Taxonomic identifieri419947 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001988: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Orotidine 5'-phosphate decarboxylasePRO_1000066479Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi419947.MRA_1394.

    Structurei

    3D structure databases

    ProteinModelPortaliA5U287.
    SMRiA5U287. Positions 4-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000245748.
    KOiK01591.
    OMAiGSTMGAY.
    OrthoDBiEOG6DZF33.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5U287-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGFGLRLAE AKARRGPLCL GIDPHPELLR GWDLATTADG LAAFCDICVR    50
    AFADFAVVKP QVAFFESYGA AGFAVLERTI AELRAADVLV LADAKRGDIG 100
    ATMSAYATAW VGDSPLAADA VTASPYLGFG SLRPLLEVAA AHGRGVFVLA 150
    ATSNPEGAAV QNAAADGRSV AQLVVDQVGA ANEAAGPGPG SIGVVVGATA 200
    PQAPDLSAFT GPVLVPGVGV QGGRPEALGG LGGAASSQLL PAVAREVLRA 250
    GPGVPELRAA GERMRDAVAY LAAV 274
    Length:274
    Mass (Da):27,377
    Last modified:July 10, 2007 - v1
    Checksum:i369BAE076FB3D143
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ73137.1.
    RefSeqiYP_001282699.1. NC_009525.1.

    Genome annotation databases

    EnsemblBacteriaiABQ73137; ABQ73137; MRA_1394.
    GeneIDi5212358.
    KEGGimra:MRA_1394.
    PATRICi18142705. VBIMycTub106795_1554.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ73137.1 .
    RefSeqi YP_001282699.1. NC_009525.1.

    3D structure databases

    ProteinModelPortali A5U287.
    SMRi A5U287. Positions 4-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 419947.MRA_1394.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ73137 ; ABQ73137 ; MRA_1394 .
    GeneIDi 5212358.
    KEGGi mra:MRA_1394.
    PATRICi 18142705. VBIMycTub106795_1554.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000245748.
    KOi K01591.
    OMAi GSTMGAY.
    OrthoDBi EOG6DZF33.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci MTUB419947:GJ8N-1441-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
      Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25177 / H37Ra.

    Entry informationi

    Entry nameiPYRF_MYCTA
    AccessioniPrimary (citable) accession number: A5U287
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3