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A5U1Z5 (A5U1Z5_MYCTA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP MF_00384
Short name=HK HAMAP MF_00384
Short name=HSK HAMAP MF_00384
EC=2.7.1.39 HAMAP MF_00384
Gene names
Name:thrB HAMAP MF_00384 EMBL ABQ73045.1
Ordered Locus Names:MRA_1304
OrganismMycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]
Taxonomic identifier419947 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384 SAAS SAAS006203

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384 SAAS SAAS006203

Subcellular location

Cytoplasm By similarity HAMAP MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. RuleBase RU004209

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP MF_00384

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding97 – 10711ATP By similarity HAMAP MF_00384

Sequences

Sequence LengthMass (Da)Tools
A5U1Z5 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 6C1DA36925F8A427

FASTA31632,346
        10         20         30         40         50         60 
MVTQALLPSG LVASAVVAAS SANLGPGFDS VGLALSLYDE IIVETTDSGL TVTVDGEGGD 

        70         80         90        100        110        120 
QVPLGPEHLV VRAVQHGLQA AGVSAAGLAV RCRNAIPHSR GLGSSAAAVV GGLAAVNGLV 

       130        140        150        160        170        180 
VQTDSSPSSD AELIQLASEF EGHPDNAAAA VLGGAVVSWT DHSGDRPNYS AVSLRLHPDI 

       190        200        210        220        230        240 
RLFTAIPEQR SSTAETRVLL PAQVSHDDAR FNVSRAALLV VALTERPDLL MAATEDLLHQ 

       250        260        270        280        290        300 
PQRAAAMTAS AEYLRLLRRH NVAAALSGAG PSLIALSTDS ELPTDAVEFG AAKGFAVTEL 

       310 
TVGEAVRWSP TVRVPG

« Hide

References

[1]"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000611 Genomic DNA. Translation: ABQ73045.1.
RefSeqYP_001282607.1. NC_009525.1.

3D structure databases

ProteinModelPortalA5U1Z5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5U1Z5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000068375; EBMYCP00000066485; EBMYCG00000068370.
GeneID5212126.
GenomeReviewsGene locus MRA_1304 in contig CP000611_GR.
KEGGmra:MRA_1304.
PATRIC18142499. VBIMycTub106795_1455.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
GeneTreeEBGT00050000016145.
HOGENOMHBG646290.
OMADRLHQPY.
ProtClustDBPRK01212.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5U1Z5_MYCTA
AccessionPrimary (citable) accession number: A5U1Z5
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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