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Protein

Putative pterin-4-alpha-carbinolamine dehydratase

Gene

MRA_1170

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-1207-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pterin-4-alpha-carbinolamine dehydrataseUniRule annotation (EC:4.2.1.96UniRule annotation)
Short name:
PHSUniRule annotation
Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydrataseUniRule annotation
Pterin carbinolamine dehydrataseUniRule annotation
Short name:
PCDUniRule annotation
Gene namesi
Ordered Locus Names:MRA_1170
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9494Putative pterin-4-alpha-carbinolamine dehydratasePRO_1000050426Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA5U1K8.
SMRiA5U1K8. Positions 26-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pterin-4-alpha-carbinolamine dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410842T. Bacteria.
COG2154. LUCA.
HOGENOMiHOG000007680.
KOiK01724.
OMAiFALVTHS.
OrthoDBiEOG6S52NH.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
HAMAPiMF_00434. Pterin_4_alpha.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
PfamiPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMiSSF55248. SSF55248. 1 hit.

Sequencei

Sequence statusi: Complete.

A5U1K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLTDEQVD AALHDLNGWQ RAGGVLRRSI KFPTFMAGID AVRRVAERAE
60 70 80 90
EVNHHPDIDI RWRTVTFALV THAVGGITEN DIAMAHDIDA MFGA
Length:94
Mass (Da):10,380
Last modified:July 10, 2007 - v1
Checksum:i21F1A514995CE65A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ72908.1.
RefSeqiWP_003406082.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ72908; ABQ72908; MRA_1170.
KEGGimra:MRA_1170.
PATRICi18142203. VBIMycTub106795_1308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ72908.1.
RefSeqiWP_003406082.1. NC_009525.1.

3D structure databases

ProteinModelPortaliA5U1K8.
SMRiA5U1K8. Positions 26-92.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ72908; ABQ72908; MRA_1170.
KEGGimra:MRA_1170.
PATRICi18142203. VBIMycTub106795_1308.

Phylogenomic databases

eggNOGiENOG410842T. Bacteria.
COG2154. LUCA.
HOGENOMiHOG000007680.
KOiK01724.
OMAiFALVTHS.
OrthoDBiEOG6S52NH.

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-1207-MONOMER.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
HAMAPiMF_00434. Pterin_4_alpha.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
PfamiPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMiSSF55248. SSF55248. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv."
    Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L., Wang H., Wang S., Zhao G., Zhang Y.
    PLoS ONE 3:E2375-E2375(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25177 / H37Ra.

Entry informationi

Entry nameiPHS_MYCTA
AccessioniPrimary (citable) accession number: A5U1K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: November 11, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.