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Protein

Pantothenate kinase

Gene

coaA

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Pantothenate kinase (coaA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. no protein annotated in this organism
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1048ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-1138-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaAUniRule annotation
Ordered Locus Names:MRA_1103
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Pantothenate kinasePRO_1000043232Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi419947.MRA_1103.

Structurei

3D structure databases

ProteinModelPortaliA5U1D9.
SMRiA5U1D9. Positions 7-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CS9. Bacteria.
COG1072. LUCA.
HOGENOMiHOG000248571.
KOiK00867.
OMAiLMQRKGF.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A5U1D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLSEPSPY VEFDRRQWRA LRMSTPLALT EEELVGLRGL GEQIDLLEVE
60 70 80 90 100
EVYLPLARLI HLQVAARQRL FAATAEFLGE PQQNPDRPVP FIIGVAGSVA
110 120 130 140 150
VGKSTTARVL QALLARWDHH PRVDLVTTDG FLYPNAELQR RNLMHRKGFP
160 170 180 190 200
ESYNRRALMR FVTSVKSGSD YACAPVYSHL HYDIIPGAEQ VVRHPDILIL
210 220 230 240 250
EGLNVLQTGP TLMVSDLFDF SLYVDARIED IEQWYVSRFL AMRTTAFADP
260 270 280 290 300
ESHFHHYAAF SDSQAVVAAR EIWRTINRPN LVENILPTRP RATLVLRKDA
310
DHSINRLRLR KL
Length:312
Mass (Da):35,657
Last modified:July 10, 2007 - v1
Checksum:iF075B543AE75788D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ72839.1.
RefSeqiWP_003405790.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ72839; ABQ72839; MRA_1103.
KEGGimra:MRA_1103.
PATRICi18142040. VBIMycTub106795_1227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ72839.1.
RefSeqiWP_003405790.1. NC_009525.1.

3D structure databases

ProteinModelPortaliA5U1D9.
SMRiA5U1D9. Positions 7-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419947.MRA_1103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ72839; ABQ72839; MRA_1103.
KEGGimra:MRA_1103.
PATRICi18142040. VBIMycTub106795_1227.

Phylogenomic databases

eggNOGiENOG4105CS9. Bacteria.
COG1072. LUCA.
HOGENOMiHOG000248571.
KOiK00867.
OMAiLMQRKGF.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciMTUB419947:GJ8N-1138-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAA_MYCTA
AccessioniPrimary (citable) accession number: A5U1D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.