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Protein

Pantothenate kinase

Gene

coaA

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaAUniRule annotation
Ordered Locus Names:MRA_1103
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000432321 – 312Pantothenate kinaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi419947.MRA_1103

Structurei

3D structure databases

ProteinModelPortaliA5U1D9
SMRiA5U1D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CS9 Bacteria
COG1072 LUCA
HOGENOMiHOG000248571
KOiK00867
OMAiLMQRKGF

Family and domain databases

CDDicd02025 PanK, 1 hit
HAMAPiMF_00215 Pantothen_kinase_1, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR004566 PanK
IPR006083 PRK/URK
PANTHERiPTHR10285:SF7 PTHR10285:SF7, 1 hit
PfamiView protein in Pfam
PF00485 PRK, 1 hit
PIRSFiPIRSF000545 Pantothenate_kin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00554 panK_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A5U1D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLSEPSPY VEFDRRQWRA LRMSTPLALT EEELVGLRGL GEQIDLLEVE
60 70 80 90 100
EVYLPLARLI HLQVAARQRL FAATAEFLGE PQQNPDRPVP FIIGVAGSVA
110 120 130 140 150
VGKSTTARVL QALLARWDHH PRVDLVTTDG FLYPNAELQR RNLMHRKGFP
160 170 180 190 200
ESYNRRALMR FVTSVKSGSD YACAPVYSHL HYDIIPGAEQ VVRHPDILIL
210 220 230 240 250
EGLNVLQTGP TLMVSDLFDF SLYVDARIED IEQWYVSRFL AMRTTAFADP
260 270 280 290 300
ESHFHHYAAF SDSQAVVAAR EIWRTINRPN LVENILPTRP RATLVLRKDA
310
DHSINRLRLR KL
Length:312
Mass (Da):35,657
Last modified:July 10, 2007 - v1
Checksum:iF075B543AE75788D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA Translation: ABQ72839.1
RefSeqiWP_003405790.1, NZ_CP016972.1

Genome annotation databases

EnsemblBacteriaiABQ72839; ABQ72839; MRA_1103
KEGGimra:MRA_1103

Similar proteinsi

Entry informationi

Entry nameiCOAA_MYCTA
AccessioniPrimary (citable) accession number: A5U1D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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