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A5U123

- MPRA_MYCTA

UniProt

A5U123 - MPRA_MYCTA

Protein

Response regulator MprA

Gene

mprA

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. response to stress Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Stress response, Transcription, Transcription regulation, Two-component regulatory system, Virulence

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciMTUB419947:GJ8N-1019-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Response regulator MprA
    Alternative name(s):
    Mycobacterial persistence regulator A
    Gene namesi
    Name:mprA
    Ordered Locus Names:MRA_0988
    OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
    Taxonomic identifieri419947 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001988: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230Response regulator MprAPRO_0000308428Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei48 – 4814-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated and dephosphorylated by MprB.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi419947.MRA_0988.

    Structurei

    3D structure databases

    ProteinModelPortaliA5U123.
    SMRiA5U123. Positions 17-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 118115Response regulatoryPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0745.
    HOGENOMiHOG000034815.
    KOiK07669.
    OMAiWLRDGVS.
    OrthoDBiEOG6G4VQG.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5U123-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVRILVVDD DRAVRESLRR SLSFNGYSVE LAHDGVEALD MIASDRPDAL    50
    VLDVMMPRLD GLEVCRQLRG TGDDLPILVL TARDSVSERV AGLDAGADDY 100
    LPKPFALEEL LARMRALLRR TKPEDAAESM AMRFSDLTLD PVTREVNRGQ 150
    RRISLTRTEF ALLEMLIANP RRVLTRSRIL EEVWGFDFPT SGNALEVYVG 200
    YLRRKTEADG EPRLIHTVRG VGYVLRETPP 230
    Length:230
    Mass (Da):25,894
    Last modified:July 10, 2007 - v1
    Checksum:i7A159FED949BE001
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ72723.1.
    RefSeqiYP_001282285.1. NC_009525.1.

    Genome annotation databases

    EnsemblBacteriaiABQ72723; ABQ72723; MRA_0988.
    GeneIDi5212587.
    KEGGimra:MRA_0988.
    PATRICi18141770. VBIMycTub106795_1095.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ72723.1 .
    RefSeqi YP_001282285.1. NC_009525.1.

    3D structure databases

    ProteinModelPortali A5U123.
    SMRi A5U123. Positions 17-226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 419947.MRA_0988.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ72723 ; ABQ72723 ; MRA_0988 .
    GeneIDi 5212587.
    KEGGi mra:MRA_0988.
    PATRICi 18141770. VBIMycTub106795_1095.

    Phylogenomic databases

    eggNOGi COG0745.
    HOGENOMi HOG000034815.
    KOi K07669.
    OMAi WLRDGVS.
    OrthoDBi EOG6G4VQG.

    Enzyme and pathway databases

    BioCyci MTUB419947:GJ8N-1019-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
      Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25177 / H37Ra.

    Entry informationi

    Entry nameiMPRA_MYCTA
    AccessioniPrimary (citable) accession number: A5U123
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3