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A5U0Y6

- G6PI_MYCTA

UniProt

A5U0Y6 - G6PI_MYCTA

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei357 – 3571Proton donorUniRule annotation
    Active sitei388 – 3881UniRule annotation
    Active sitei514 – 5141UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciMTUB419947:GJ8N-982-MONOMER.
    SABIO-RKA5U0Y6.
    UniPathwayiUPA00109; UER00181.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:MRA_0953
    OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
    Taxonomic identifieri419947 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001988: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Glucose-6-phosphate isomerasePRO_1000013990Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi419947.MRA_0953.

    Structurei

    3D structure databases

    ProteinModelPortaliA5U0Y6.
    SMRiA5U0Y6. Positions 7-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000261371.
    KOiK01810.
    OMAiNCHFVAN.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5U0Y6-1 [UniParc]FASTAAdd to Basket

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    MTSAPIPDIT ATPAWDALRR HHDQIGNTHL RQFFADDPGR GRELTVSVGD    50
    LYIDYSKHRV TRETLALLID LARTAHLEER RDQMFAGVHI NTSEDRAVLH 100
    TALRLPRDAE LVVDGQDVVT DVHAVLDAMG AFTDRLRSGE WTGATGKRIS 150
    TVVNIGIGGS DLGPVMVYQA LRHYADAGIS ARFVSNVDPA DLIATLADLD 200
    PATTLFIVAS KTFSTLETLT NATAARRWLT DALGDAAVSR HFVAVSTNKR 250
    LVDDFGINTD NMFGFWDWVG GRYSVDSAIG LSLMTVIGRD AFADFLAGFH 300
    IIDRHFATAP LESNAPVLLG LIGLWYSNFF GAQSRTVLPY SNDLSRFPAY 350
    LQQLTMESNG KSTRADGSPV SADTGEIFWG EPGTNGQHAF YQLLHQGTRL 400
    VPADFIGFAQ PLDDLPTAEG TGSMHDLLMS NFFAQTQVLA FGKTAEEIAA 450
    DGTPAHVVAH KVMPGNRPST SILASRLTPS VLGQLIALYE HQVFTEGVVW 500
    GIDSFDQWGV ELGKTQAKAL LPVITGAGSP PPQSDSSTDG LVRRYRTERG 550
    RAG 553
    Length:553
    Mass (Da):59,974
    Last modified:July 10, 2007 - v1
    Checksum:iFB57DFFD16386AE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ72686.1.
    RefSeqiYP_001282248.1. NC_009525.1.

    Genome annotation databases

    EnsemblBacteriaiABQ72686; ABQ72686; MRA_0953.
    GeneIDi5214065.
    KEGGimra:MRA_0953.
    PATRICi18141687. VBIMycTub106795_1054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ72686.1 .
    RefSeqi YP_001282248.1. NC_009525.1.

    3D structure databases

    ProteinModelPortali A5U0Y6.
    SMRi A5U0Y6. Positions 7-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 419947.MRA_0953.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ72686 ; ABQ72686 ; MRA_0953 .
    GeneIDi 5214065.
    KEGGi mra:MRA_0953.
    PATRICi 18141687. VBIMycTub106795_1054.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000261371.
    KOi K01810.
    OMAi NCHFVAN.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    UPA00138 .
    BioCyci MTUB419947:GJ8N-982-MONOMER.
    SABIO-RK A5U0Y6.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
      Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25177 / H37Ra.

    Entry informationi

    Entry nameiG6PI_MYCTA
    AccessioniPrimary (citable) accession number: A5U0Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3