A5U0P1 (KDC_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-keto-acid decarboxylase
Short name=KDC
EC=4.1.1.-

Gene names

Name:	kdc
Ordered Locus Names:	MRA_0861

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.
Cofactor	Binds 1 metal ion per subunit By similarity. Binds 1 thiamine pyrophosphate per subunit By similarity.
Sequence similarities	Belongs to the TPP enzyme family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding Thiamine pyrophosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	carboxy-lyase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: InterPro thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Alpha-keto-acid decarboxylase		PRO_0000333752
Regions
	Region	396 – 478	83	Thiamine pyrophosphate binding By similarity
Sites
	Metal binding	446	1	Magnesium By similarity
	Metal binding	473	1	Magnesium By similarity
	Metal binding	475	1	Magnesium; via carbonyl oxygen By similarity
	Binding site	61	1	Thiamine pyrophosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5U0P1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: F0430F720D57B7C4	FASTA	560	59,783
	10 20 30 40 50 60 MTPQKSDACS DPVYTVGDYL LDRLAELGVS EIFGVPGDYN LQFLDHIVAH PTIRWVGSAN 70 80 90 100 110 120 ELNAGYAADG YGRLRGMSAV VTTFGVGELS VTNAIAGSYA EHVPVVHIVG GPTKDAQGTR 130 140 150 160 170 180 RALHHSLGDG DFEHFLRISR EITCAQANLM PATAGREIDR VLSEVREQKR PGYILLSSDV 190 200 210 220 230 240 ARFPTEPPAA PLPRYPGGTS PRALSLFTKA AIELIADHQL TVLADLLVHR LQAVKELEAL 250 260 270 280 290 300 LAADVVPHAT LMWGKSLLDE SSPNFLGIYA GAASAERVRA AIEGAPVLVT AGVVFTDMVS 310 320 330 340 350 360 GFFSQRIDPA RTIDIGQYQS SVADQVFAPL EMSAALQALA TILTGRGISS PPVVPPPAEP 370 380 390 400 410 420 PPAMPARDEP LTQQMVWDRV CSALTPGNVV LADQGTSFYG MADHRLPQGV TFIGQPLWGS 430 440 450 460 470 480 IGYTLPAAVG AAVAHPDRRT VLLIGDGAAQ LTVQELGTFS REGLSPVIVV VNNDGYTVER 490 500 510 520 530 540 AIHGETAPYN DIVSWNWTEL PSALGVTNHL AFRAQTYGQL DDALTVAAAR RDRMVLVEVV 550 560 LPRLEIPRLL GQLVGSMAPQ

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ72591.1.
RefSeq	YP_001282153.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U0P1.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U0P1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000066542; EBMYCP00000064652; EBMYCG00000066537.
GeneID	5214646.
GenomeReviews	Gene locus MRA_0861 in contig CP000611_GR.
KEGG	mra:MRA_0861.
PATRIC	18141483. VBIMycTub106795_0953.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3961.
GeneTree	EBGT00050000014643.
HOGENOM	HBG479104.
OMA	DIILADQ.
ProtClustDB	CLSK790786.
Enzyme and pathway databases
BioCyc	MTUB419947:MRA_0861-MONOMER.
Family and domain databases
InterPro	IPR012110. Pyruvt_ip_decrb. IPR012000. Thiamin_PyroP_enz_cen_dom. IPR012001. Thiamin_PyroP_enz_TPP-bd_dom. IPR000399. TPP-bd_CS. IPR011766. TPP_enzyme-bd_C. [Graphical view]
KO	K04103.
PANTHER	PTHR18968:SF4. PTHR18968:SF4. 1 hit.
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF00205. TPP_enzyme_M. 1 hit. PF02776. TPP_enzyme_N. 1 hit. [Graphical view]
PIRSF	PIRSF036565. Pyruvt_ip_decrb. 1 hit.
PROSITE	PS00187. TPP_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KDC_MYCTA

Accession

Primary (citable) accession number: A5U0P1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program