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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei179DesacetylmycothiolUniRule annotation1
Binding sitei224DesacetylmycothiolUniRule annotation1
Binding sitei234DesacetylmycothiolUniRule annotation1
Binding sitei282Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:MRA_0829
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002791 – 315Mycothiol acetyltransferaseAdd BLAST315

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi419947.MtubH3_010100005507.

Structurei

3D structure databases

ProteinModelPortaliA5U0K8.
SMRiA5U0K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 141N-acetyltransferase 1UniRule annotationAdd BLAST138
Domaini152 – 315N-acetyltransferase 2UniRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 82Acetyl-CoA binding 1UniRule annotation3
Regioni88 – 93Acetyl-CoA binding 1UniRule annotation6
Regioni238 – 240Acetyl-CoA binding 2UniRule annotation3
Regioni245 – 251Acetyl-CoA binding 2UniRule annotation7
Regioni287 – 292Acetyl-CoA binding 2UniRule annotation6

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5U0K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALDWRSAL TADEQRSVRA LVTATTAVDG VAPVGEQVLR ELGQQRTEHL
60 70 80 90 100
LVAGSRPGGP IIGYLNLSPP RGAGGAMAEL VVHPQSRRRG IGTAMARAAL
110 120 130 140 150
AKTAGRNQFW AHGTLDPARA TASALGLVGV RELIQMRRPL RDIPEPTIPD
160 170 180 190 200
GVVIRTYAGT SDDAELLRVN NAAFAGHPEQ GGWTAVQLAE RRGEAWFDPD
210 220 230 240 250
GLILAFGDSP RERPGRLLGF HWTKVHPDHP GLGEVYVLGV DPAAQRRGLG
260 270 280 290 300
QMLTSIGIVS LARRLGGRKT LDPAVEPAVL LYVESDNVAA VRTYQSLGFT
310
TYSVDTAYAL AGTDN
Length:315
Mass (Da):33,599
Last modified:July 10, 2007 - v1
Checksum:iE1728C0652CF2716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ72558.1.
RefSeqiWP_003404307.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ72558; ABQ72558; MRA_0829.
KEGGimra:MRA_0829.
PATRICi18141393. VBIMycTub106795_0912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ72558.1.
RefSeqiWP_003404307.1. NC_009525.1.

3D structure databases

ProteinModelPortaliA5U0K8.
SMRiA5U0K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419947.MtubH3_010100005507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ72558; ABQ72558; MRA_0829.
KEGGimra:MRA_0829.
PATRICi18141393. VBIMycTub106795_0912.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHD_MYCTA
AccessioniPrimary (citable) accession number: A5U0K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.