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Protein
Submitted name:

NAD-dependent aldehyde dehydrogenase AldA

Gene

aldA

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-797-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
NAD-dependent aldehyde dehydrogenase AldAImported
Gene namesi
Name:aldAImported
Ordered Locus Names:MRA_0777Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)Imported
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001988 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi419947.MRA_0777.

Structurei

3D structure databases

ProteinModelPortaliA5U0F6.
SMRiA5U0F6. Positions 30-484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiWASCPAN.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR026460. Aldehyde_dehydrogenase_Rv0768.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR04284. aldehy_Rv0768. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5U0F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWGDGISA LLIDGKLSDG RAGTFPTVNP ATEEVLGVAA DADAEDMGRA
60 70 80 90 100
IEAARRAFDS TDWSRNTELR VRCVRQLRDA MQQHVEELRE LTISEVGAPR
110 120 130 140 150
MLTASAQLEG PVGDLSFAAD TAESYPWKQD LGEASPLGIA TRRTLAREAV
160 170 180 190 200
GVVGAITPWN FPHQINLAKL GPALAAGNTV VLKPAPDTPW CAAALGEIIV
210 220 230 240 250
EHTDFPPGVV NIVTSSSHAL GALLAKDPRV DMISFTGSTA TGRAVMADAA
260 270 280 290 300
ATIKKVFLEL GGKSAFVVLD DADLAAASAV SAFSACMHAG QGCAITTRLV
310 320 330 340 350
VPRARYEEAV AIAAATMSSI RPGDPNDPGT VCGPLISARQ RDRVQGYLDL
360 370 380 390 400
AVAEGGRFAC GGARPADREV GFYIEPTVIA GLTNDARVAR EEIFGPVLTV
410 420 430 440 450
IAHDGDDDAV RIANDSPYGL SGTVYGADPQ RAARIASRLR VGTVNVNGGV
460 470 480
WYCADAPFGG YKQSGIGREM GLLGFEEYLE AKLIATAAN
Length:489
Mass (Da):51,184
Last modified:July 10, 2007 - v1
Checksum:i2E2E797008030738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ72506.1.
RefSeqiWP_003403919.1. NZ_AAYK01000247.1.
YP_001282068.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ72506; ABQ72506; MRA_0777.
KEGGimra:MRA_0777.
PATRICi18141278. VBIMycTub106795_0855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA. Translation: ABQ72506.1.
RefSeqiWP_003403919.1. NZ_AAYK01000247.1.
YP_001282068.1. NC_009525.1.

3D structure databases

ProteinModelPortaliA5U0F6.
SMRiA5U0F6. Positions 30-484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419947.MRA_0777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ72506; ABQ72506; MRA_0777.
KEGGimra:MRA_0777.
PATRICi18141278. VBIMycTub106795_0855.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiWASCPAN.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-797-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR026460. Aldehyde_dehydrogenase_Rv0768.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR04284. aldehy_Rv0768. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv."
    Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L., Wang H., Wang S., Zhao G., Zhang Y.
    PLoS ONE 3:E2375-E2375(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25177 / H37RaImported.

Entry informationi

Entry nameiA5U0F6_MYCTA
AccessioniPrimary (citable) accession number: A5U0F6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 27, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.