A5U0A5 (RL6_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L6

Gene names

Name:	rplF
Ordered Locus Names:	MRA_0727

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center By similarity. HAMAP MF_01365_B
Subunit structure	Part of the 50S ribosomal subunit By similarity. HAMAP MF_01365_B
Sequence similarities	Belongs to the ribosomal protein L6P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	50S ribosomal protein L6 HAMAP MF_01365_B		PRO_1000055269

Sequences

	Sequence		Length	Mass (Da)
	A5U0A5 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 70C5F357B7C452E9	FASTA	179	19,377
	10 20 30 40 50 60 MSRIGKQPIP VPAGVDVTIE GQSISVKGPK GTLGLTVAEP IKVARNDDGA IVVTRPDDER 70 80 90 100 110 120 RNRSLHGLSR TLVSNLVTGV TQGYTTKMEI FGVGYRVQLK GSNLEFALGY SHPVVIEAPE 130 140 150 160 170 GITFAVQAPT KFTVSGIDKQ KVGQIAANIR RLRRPDPYKG KGVRYEGEQI RRKVGKTGK

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ72455.1.
RefSeq	YP_001282017.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5U0A5.
SMR	A5U0A5. Positions 7-179.
ModBase	Search...
Protein-protein interaction databases
STRING	A5U0A5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000067116; EBMYCP00000065226; EBMYCG00000067111.
GeneID	5213195.
GenomeReviews	Gene locus MRA_0727 in contig CP000611_GR.
KEGG	mra:MRA_0727.
PATRIC	18141168. VBIMycTub106795_0801.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0097.
GeneTree	EBGT00050000015590.
HOGENOM	HBG606796.
OMA	ALINNMV.
ProtClustDB	PRK05498.
Enzyme and pathway databases
BioCyc	MTUB419947:MRA_0727-MONOMER.
Family and domain databases
HAMAP	MF_01365_B. Ribosomal_L6_B. [Tree]
InterPro	IPR000702. Ribosomal_L6. IPR020040. Ribosomal_L6_a/b-dom. IPR019906. Ribosomal_L6_bac-type. IPR002358. Ribosomal_L6_CS. [Graphical view]
Gene3D	G3DSA:3.90.930.12. Ribosomal_L6. 2 hits.
KO	K02933.
PANTHER	PTHR11655:SF6. PTHR11655:SF6. 1 hit. PTHR11655. Ribosomal_L6. 1 hit.
Pfam	PF00347. Ribosomal_L6. 2 hits. [Graphical view]
PIRSF	PIRSF002162. Ribosomal_L6. 1 hit.
PRINTS	PR00059. RIBOSOMALL6.
SUPFAM	SSF56053. Ribosomal_L6. 2 hits.
TIGRFAMs	TIGR03654. L6_bact. 1 hit.
PROSITE	PS00525. RIBOSOMAL_L6_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL6_MYCTA

Accession

Primary (citable) accession number: A5U0A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program