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A5U053

- RPOC_MYCTA

UniProt

A5U053 - RPOC_MYCTA

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Protein
DNA-directed RNA polymerase subunit beta'
Gene
rpoC, MRA_0677
Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-693-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit beta' (EC:2.7.7.6)
Short name:
RNAP subunit beta'
Alternative name(s):
RNA polymerase subunit beta'
Transcriptase subunit beta'
Gene namesi
Name:rpoC
Ordered Locus Names:MRA_0677
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001988: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13161316DNA-directed RNA polymerase subunit beta'UniRule annotation
PRO_0000308859Add
BLAST

Proteomic databases

PRIDEiA5U053.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Protein-protein interaction databases

STRINGi419947.MRA_0677.

Structurei

3D structure databases

ProteinModelPortaliA5U053.
SMRiA5U053. Positions 9-173, 203-1282.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0086.
HOGENOMiHOG000218386.
KOiK03046.
OMAiAYDSEFL.
OrthoDBiEOG6M9DS6.

Family and domain databases

HAMAPiMF_01322. RNApol_bact_RpoC.
InterProiIPR012754. DNA-dir_RpoC_beta_prime.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view]
PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
SMARTiSM00663. RPOLA_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02386. rpoC_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

A5U053-1 [UniParc]FASTAAdd to Basket

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MLDVNFFDEL RIGLATAEDI RQWSYGEVKK PETINYRTLK PEKDGLFCEK     50
IFGPTRDWEC YCGKYKRVRF KGIICERCGV EVTRAKVRRE RMGHIELAAP 100
VTHIWYFKGV PSRLGYLLDL APKDLEKIIY FAAYVITSVD EEMRHNELST 150
LEAEMAVERK AVEDQRDGEL EARAQKLEAD LAELEAEGAK ADARRKVRDG 200
GEREMRQIRD RAQRELDRLE DIWSTFTKLA PKQLIVDENL YRELVDRYGE 250
YFTGAMGAES IQKLIENFDI DAEAESLRDV IRNGKGQKKL RALKRLKVVA 300
AFQQSGNSPM GMVLDAVPVI PPELRPMVQL DGGRFATSDL NDLYRRVINR 350
NNRLKRLIDL GAPEIIVNNE KRMLQESVDA LFDNGRRGRP VTGPGNRPLK 400
SLSDLLKGKQ GRFRQNLLGK RVDYSGRSVI VVGPQLKLHQ CGLPKLMALE 450
LFKPFVMKRL VDLNHAQNIK SAKRMVERQR PQVWDVLEEV IAEHPVLLNR 500
APTLHRLGIQ AFEPMLVEGK AIQLHPLVCE AFNADFDGDQ MAVHLPLSAE 550
AQAEARILML SSNNILSPAS GRPLAMPRLD MVTGLYYLTT EVPGDTGEYQ 600
PASGDHPETG VYSSPAEAIM AADRGVLSVR AKIKVRLTQL RPPVEIEAEL 650
FGHSGWQPGD AWMAETTLGR VMFNELLPLG YPFVNKQMHK KVQAAIINDL 700
AERYPMIVVA QTVDKLKDAG FYWATRSGVT VSMADVLVPP RKKEILDHYE 750
ERADKVEKQF QRGALNHDER NEALVEIWKE ATDEVGQALR EHYPDDNPII 800
TIVDSGATGN FTQTRTLAGM KGLVTNPKGE FIPRPVKSSF REGLTVLEYF 850
INTHGARKGL ADTALRTADS GYLTRRLVDV SQDVIVREHD CQTERGIVVE 900
LAERAPDGTL IRDPYIETSA YARTLGTDAV DEAGNVIVER GQDLGDPEID 950
ALLAAGITQV KVRSVLTCAT STGVCATCYG RSMATGKLVD IGEAVGIVAA 1000
QSIGEPGTQL TMRTFHQGGV GEDITGGLPR VQELFEARVP RGKAPIADVT 1050
GRVRLEDGER FYKITIVPDD GGEEVVYDKI SKRQRLRVFK HEDGSERVLS 1100
DGDHVEVGQQ LMEGSADPHE VLRVQGPREV QIHLVREVQE VYRAQGVSIH 1150
DKHIEVIVRQ MLRRVTIIDS GSTEFLPGSL IDRAEFEAEN RRVVAEGGEP 1200
AAGRPVLMGI TKASLATDSW LSAASFQETT RVLTDAAINC RSDKLNGLKE 1250
NVIIGKLIPA GTGINRYRNI AVQPTEEARA AAYTIPSYED QYYSPDFGAA 1300
TGAAVPLDDY GYSDYR 1316
Length:1,316
Mass (Da):146,769
Last modified:July 10, 2007 - v1
Checksum:i45BF24839AF53E8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000611 Genomic DNA. Translation: ABQ72403.1.
RefSeqiYP_001281965.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ72403; ABQ72403; MRA_0677.
GeneIDi5211646.
KEGGimra:MRA_0677.
PATRICi18141050. VBIMycTub106795_0742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000611 Genomic DNA. Translation: ABQ72403.1 .
RefSeqi YP_001281965.1. NC_009525.1.

3D structure databases

ProteinModelPortali A5U053.
SMRi A5U053. Positions 9-173, 203-1282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419947.MRA_0677.

Proteomic databases

PRIDEi A5U053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ72403 ; ABQ72403 ; MRA_0677 .
GeneIDi 5211646.
KEGGi mra:MRA_0677.
PATRICi 18141050. VBIMycTub106795_0742.

Phylogenomic databases

eggNOGi COG0086.
HOGENOMi HOG000218386.
KOi K03046.
OMAi AYDSEFL.
OrthoDBi EOG6M9DS6.

Enzyme and pathway databases

BioCyci MTUB419947:GJ8N-693-MONOMER.

Family and domain databases

HAMAPi MF_01322. RNApol_bact_RpoC.
InterProi IPR012754. DNA-dir_RpoC_beta_prime.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view ]
Pfami PF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view ]
SMARTi SM00663. RPOLA_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02386. rpoC_TIGR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
    Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25177 / H37Ra.

Entry informationi

Entry nameiRPOC_MYCTA
AccessioniPrimary (citable) accession number: A5U053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 10, 2007
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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