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A5U053

- RPOC_MYCTA

UniProt

A5U053 - RPOC_MYCTA

Protein

DNA-directed RNA polymerase subunit beta'

Gene

rpoC

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    BioCyciMTUB419947:GJ8N-693-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit beta'UniRule annotation (EC:2.7.7.6UniRule annotation)
    Short name:
    RNAP subunit beta'UniRule annotation
    Alternative name(s):
    RNA polymerase subunit beta'UniRule annotation
    Transcriptase subunit beta'UniRule annotation
    Gene namesi
    Name:rpoCUniRule annotation
    Ordered Locus Names:MRA_0677
    OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
    Taxonomic identifieri419947 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001988: Chromosome

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13161316DNA-directed RNA polymerase subunit beta'PRO_0000308859Add
    BLAST

    Proteomic databases

    PRIDEiA5U053.

    Interactioni

    Subunit structurei

    The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

    Protein-protein interaction databases

    STRINGi419947.MRA_0677.

    Structurei

    3D structure databases

    ProteinModelPortaliA5U053.
    SMRiA5U053. Positions 9-173, 203-1282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA polymerase beta' chain family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0086.
    HOGENOMiHOG000218386.
    KOiK03046.
    OMAiAYDSEFL.
    OrthoDBiEOG6M9DS6.

    Family and domain databases

    HAMAPiMF_01322. RNApol_bact_RpoC.
    InterProiIPR012754. DNA-dir_RpoC_beta_prime.
    IPR000722. RNA_pol_asu.
    IPR006592. RNA_pol_N.
    IPR007080. RNA_pol_Rpb1_1.
    IPR007066. RNA_pol_Rpb1_3.
    IPR007083. RNA_pol_Rpb1_4.
    IPR007081. RNA_pol_Rpb1_5.
    [Graphical view]
    PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
    PF00623. RNA_pol_Rpb1_2. 1 hit.
    PF04983. RNA_pol_Rpb1_3. 1 hit.
    PF05000. RNA_pol_Rpb1_4. 1 hit.
    PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view]
    SMARTiSM00663. RPOLA_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02386. rpoC_TIGR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5U053-1 [UniParc]FASTAAdd to Basket

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    MLDVNFFDEL RIGLATAEDI RQWSYGEVKK PETINYRTLK PEKDGLFCEK     50
    IFGPTRDWEC YCGKYKRVRF KGIICERCGV EVTRAKVRRE RMGHIELAAP 100
    VTHIWYFKGV PSRLGYLLDL APKDLEKIIY FAAYVITSVD EEMRHNELST 150
    LEAEMAVERK AVEDQRDGEL EARAQKLEAD LAELEAEGAK ADARRKVRDG 200
    GEREMRQIRD RAQRELDRLE DIWSTFTKLA PKQLIVDENL YRELVDRYGE 250
    YFTGAMGAES IQKLIENFDI DAEAESLRDV IRNGKGQKKL RALKRLKVVA 300
    AFQQSGNSPM GMVLDAVPVI PPELRPMVQL DGGRFATSDL NDLYRRVINR 350
    NNRLKRLIDL GAPEIIVNNE KRMLQESVDA LFDNGRRGRP VTGPGNRPLK 400
    SLSDLLKGKQ GRFRQNLLGK RVDYSGRSVI VVGPQLKLHQ CGLPKLMALE 450
    LFKPFVMKRL VDLNHAQNIK SAKRMVERQR PQVWDVLEEV IAEHPVLLNR 500
    APTLHRLGIQ AFEPMLVEGK AIQLHPLVCE AFNADFDGDQ MAVHLPLSAE 550
    AQAEARILML SSNNILSPAS GRPLAMPRLD MVTGLYYLTT EVPGDTGEYQ 600
    PASGDHPETG VYSSPAEAIM AADRGVLSVR AKIKVRLTQL RPPVEIEAEL 650
    FGHSGWQPGD AWMAETTLGR VMFNELLPLG YPFVNKQMHK KVQAAIINDL 700
    AERYPMIVVA QTVDKLKDAG FYWATRSGVT VSMADVLVPP RKKEILDHYE 750
    ERADKVEKQF QRGALNHDER NEALVEIWKE ATDEVGQALR EHYPDDNPII 800
    TIVDSGATGN FTQTRTLAGM KGLVTNPKGE FIPRPVKSSF REGLTVLEYF 850
    INTHGARKGL ADTALRTADS GYLTRRLVDV SQDVIVREHD CQTERGIVVE 900
    LAERAPDGTL IRDPYIETSA YARTLGTDAV DEAGNVIVER GQDLGDPEID 950
    ALLAAGITQV KVRSVLTCAT STGVCATCYG RSMATGKLVD IGEAVGIVAA 1000
    QSIGEPGTQL TMRTFHQGGV GEDITGGLPR VQELFEARVP RGKAPIADVT 1050
    GRVRLEDGER FYKITIVPDD GGEEVVYDKI SKRQRLRVFK HEDGSERVLS 1100
    DGDHVEVGQQ LMEGSADPHE VLRVQGPREV QIHLVREVQE VYRAQGVSIH 1150
    DKHIEVIVRQ MLRRVTIIDS GSTEFLPGSL IDRAEFEAEN RRVVAEGGEP 1200
    AAGRPVLMGI TKASLATDSW LSAASFQETT RVLTDAAINC RSDKLNGLKE 1250
    NVIIGKLIPA GTGINRYRNI AVQPTEEARA AAYTIPSYED QYYSPDFGAA 1300
    TGAAVPLDDY GYSDYR 1316
    Length:1,316
    Mass (Da):146,769
    Last modified:July 10, 2007 - v1
    Checksum:i45BF24839AF53E8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ72403.1.
    RefSeqiYP_001281965.1. NC_009525.1.

    Genome annotation databases

    EnsemblBacteriaiABQ72403; ABQ72403; MRA_0677.
    GeneIDi5211646.
    KEGGimra:MRA_0677.
    PATRICi18141050. VBIMycTub106795_0742.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000611 Genomic DNA. Translation: ABQ72403.1 .
    RefSeqi YP_001281965.1. NC_009525.1.

    3D structure databases

    ProteinModelPortali A5U053.
    SMRi A5U053. Positions 9-173, 203-1282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 419947.MRA_0677.

    Proteomic databases

    PRIDEi A5U053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ72403 ; ABQ72403 ; MRA_0677 .
    GeneIDi 5211646.
    KEGGi mra:MRA_0677.
    PATRICi 18141050. VBIMycTub106795_0742.

    Phylogenomic databases

    eggNOGi COG0086.
    HOGENOMi HOG000218386.
    KOi K03046.
    OMAi AYDSEFL.
    OrthoDBi EOG6M9DS6.

    Enzyme and pathway databases

    BioCyci MTUB419947:GJ8N-693-MONOMER.

    Family and domain databases

    HAMAPi MF_01322. RNApol_bact_RpoC.
    InterProi IPR012754. DNA-dir_RpoC_beta_prime.
    IPR000722. RNA_pol_asu.
    IPR006592. RNA_pol_N.
    IPR007080. RNA_pol_Rpb1_1.
    IPR007066. RNA_pol_Rpb1_3.
    IPR007083. RNA_pol_Rpb1_4.
    IPR007081. RNA_pol_Rpb1_5.
    [Graphical view ]
    Pfami PF04997. RNA_pol_Rpb1_1. 1 hit.
    PF00623. RNA_pol_Rpb1_2. 1 hit.
    PF04983. RNA_pol_Rpb1_3. 1 hit.
    PF05000. RNA_pol_Rpb1_4. 1 hit.
    PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view ]
    SMARTi SM00663. RPOLA_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02386. rpoC_TIGR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
      Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25177 / H37Ra.

    Entry informationi

    Entry nameiRPOC_MYCTA
    AccessioniPrimary (citable) accession number: A5U053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3