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A5U053

- RPOC_MYCTA

UniProt

A5U053 - RPOC_MYCTA

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Protein

DNA-directed RNA polymerase subunit beta'

Gene

rpoC

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciMTUB419947:GJ8N-693-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit beta'UniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit beta'UniRule annotation
Alternative name(s):
RNA polymerase subunit beta'UniRule annotation
Transcriptase subunit beta'UniRule annotation
Gene namesi
Name:rpoCUniRule annotation
Ordered Locus Names:MRA_0677
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001988: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13161316DNA-directed RNA polymerase subunit beta'PRO_0000308859Add
BLAST

Proteomic databases

PRIDEiA5U053.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi419947.MRA_0677.

Structurei

3D structure databases

ProteinModelPortaliA5U053.
SMRiA5U053. Positions 9-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0086.
HOGENOMiHOG000218386.
KOiK03046.
OMAiAYDSEFL.
OrthoDBiEOG6M9DS6.

Family and domain databases

HAMAPiMF_01322. RNApol_bact_RpoC.
InterProiIPR012754. DNA-dir_RpoC_beta_prime.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view]
PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
SMARTiSM00663. RPOLA_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02386. rpoC_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

A5U053-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDVNFFDEL RIGLATAEDI RQWSYGEVKK PETINYRTLK PEKDGLFCEK
60 70 80 90 100
IFGPTRDWEC YCGKYKRVRF KGIICERCGV EVTRAKVRRE RMGHIELAAP
110 120 130 140 150
VTHIWYFKGV PSRLGYLLDL APKDLEKIIY FAAYVITSVD EEMRHNELST
160 170 180 190 200
LEAEMAVERK AVEDQRDGEL EARAQKLEAD LAELEAEGAK ADARRKVRDG
210 220 230 240 250
GEREMRQIRD RAQRELDRLE DIWSTFTKLA PKQLIVDENL YRELVDRYGE
260 270 280 290 300
YFTGAMGAES IQKLIENFDI DAEAESLRDV IRNGKGQKKL RALKRLKVVA
310 320 330 340 350
AFQQSGNSPM GMVLDAVPVI PPELRPMVQL DGGRFATSDL NDLYRRVINR
360 370 380 390 400
NNRLKRLIDL GAPEIIVNNE KRMLQESVDA LFDNGRRGRP VTGPGNRPLK
410 420 430 440 450
SLSDLLKGKQ GRFRQNLLGK RVDYSGRSVI VVGPQLKLHQ CGLPKLMALE
460 470 480 490 500
LFKPFVMKRL VDLNHAQNIK SAKRMVERQR PQVWDVLEEV IAEHPVLLNR
510 520 530 540 550
APTLHRLGIQ AFEPMLVEGK AIQLHPLVCE AFNADFDGDQ MAVHLPLSAE
560 570 580 590 600
AQAEARILML SSNNILSPAS GRPLAMPRLD MVTGLYYLTT EVPGDTGEYQ
610 620 630 640 650
PASGDHPETG VYSSPAEAIM AADRGVLSVR AKIKVRLTQL RPPVEIEAEL
660 670 680 690 700
FGHSGWQPGD AWMAETTLGR VMFNELLPLG YPFVNKQMHK KVQAAIINDL
710 720 730 740 750
AERYPMIVVA QTVDKLKDAG FYWATRSGVT VSMADVLVPP RKKEILDHYE
760 770 780 790 800
ERADKVEKQF QRGALNHDER NEALVEIWKE ATDEVGQALR EHYPDDNPII
810 820 830 840 850
TIVDSGATGN FTQTRTLAGM KGLVTNPKGE FIPRPVKSSF REGLTVLEYF
860 870 880 890 900
INTHGARKGL ADTALRTADS GYLTRRLVDV SQDVIVREHD CQTERGIVVE
910 920 930 940 950
LAERAPDGTL IRDPYIETSA YARTLGTDAV DEAGNVIVER GQDLGDPEID
960 970 980 990 1000
ALLAAGITQV KVRSVLTCAT STGVCATCYG RSMATGKLVD IGEAVGIVAA
1010 1020 1030 1040 1050
QSIGEPGTQL TMRTFHQGGV GEDITGGLPR VQELFEARVP RGKAPIADVT
1060 1070 1080 1090 1100
GRVRLEDGER FYKITIVPDD GGEEVVYDKI SKRQRLRVFK HEDGSERVLS
1110 1120 1130 1140 1150
DGDHVEVGQQ LMEGSADPHE VLRVQGPREV QIHLVREVQE VYRAQGVSIH
1160 1170 1180 1190 1200
DKHIEVIVRQ MLRRVTIIDS GSTEFLPGSL IDRAEFEAEN RRVVAEGGEP
1210 1220 1230 1240 1250
AAGRPVLMGI TKASLATDSW LSAASFQETT RVLTDAAINC RSDKLNGLKE
1260 1270 1280 1290 1300
NVIIGKLIPA GTGINRYRNI AVQPTEEARA AAYTIPSYED QYYSPDFGAA
1310
TGAAVPLDDY GYSDYR
Length:1,316
Mass (Da):146,769
Last modified:July 10, 2007 - v1
Checksum:i45BF24839AF53E8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000611 Genomic DNA. Translation: ABQ72403.1.
RefSeqiYP_001281965.1. NC_009525.1.

Genome annotation databases

EnsemblBacteriaiABQ72403; ABQ72403; MRA_0677.
GeneIDi5211646.
KEGGimra:MRA_0677.
PATRICi18141050. VBIMycTub106795_0742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000611 Genomic DNA. Translation: ABQ72403.1 .
RefSeqi YP_001281965.1. NC_009525.1.

3D structure databases

ProteinModelPortali A5U053.
SMRi A5U053. Positions 9-136.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419947.MRA_0677.

Proteomic databases

PRIDEi A5U053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ72403 ; ABQ72403 ; MRA_0677 .
GeneIDi 5211646.
KEGGi mra:MRA_0677.
PATRICi 18141050. VBIMycTub106795_0742.

Phylogenomic databases

eggNOGi COG0086.
HOGENOMi HOG000218386.
KOi K03046.
OMAi AYDSEFL.
OrthoDBi EOG6M9DS6.

Enzyme and pathway databases

BioCyci MTUB419947:GJ8N-693-MONOMER.

Family and domain databases

HAMAPi MF_01322. RNApol_bact_RpoC.
InterProi IPR012754. DNA-dir_RpoC_beta_prime.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view ]
Pfami PF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view ]
SMARTi SM00663. RPOLA_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02386. rpoC_TIGR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
    Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25177 / H37Ra.

Entry informationi

Entry nameiRPOC_MYCTA
AccessioniPrimary (citable) accession number: A5U053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3