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Protein

Cyclopropane mycolic acid synthase MmaA2

Gene

mmaA2

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. MmaA2 also catalyzes the biosynthesis of the cis-cyclopropanated methoxymycolates. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.

Pathwayi: mycolic acid biosynthesis

This protein is involved in the pathway mycolic acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mycolic acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Active sitei269By similarity1

GO - Molecular functioni

  • cyclopropane-fatty-acyl-phospholipid synthase activity Source: UniProtKB
  • methyltransferase activity Source: UniProtKB

GO - Biological processi

  • lipid biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00915

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclopropane mycolic acid synthase MmaA2 (EC:2.1.1.79)
Short name:
CMAS
Alternative name(s):
Cyclopropane-fatty-acyl-phospholipid synthase
Short name:
CFA synthase
Mycolic acid methyltransferase
Short name:
MA-MT
S-adenosylmethionine-dependent methyltransferase
Short name:
AdoMet-MT
Short name:
SAM-MT
Gene namesi
Name:mmaA2
Synonyms:mma2
Ordered Locus Names:MRA_0655
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003983611 – 287Cyclopropane mycolic acid synthase MmaA2Add BLAST287

Interactioni

Protein-protein interaction databases

STRINGi419947.MtubH3_010100002388

Structurei

3D structure databases

ProteinModelPortaliA5U029
SMRiA5U029
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 34S-adenosyl-L-methionine bindingBy similarity2
Regioni72 – 74S-adenosyl-L-methionine bindingBy similarity3
Regioni94 – 99S-adenosyl-L-methionine bindingBy similarity6
Regioni123 – 124S-adenosyl-L-methionine bindingBy similarity2

Sequence similaritiesi

Belongs to the CFA/CMAS family.Curated

Phylogenomic databases

eggNOGiENOG4108NUI Bacteria
COG2230 LUCA
HOGENOMiHOG000245191
KOiK00574
OMAiLHCITAQ

Family and domain databases

InterProiView protein in InterPro
IPR003333 Mycolic_cyclopropane_synthase
IPR029063 SAM-dependent_MTases
PIRSFiPIRSF003085 CMAS, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

A5U029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNDLTPHFE DVQAHYDLSD DFFRLFLDPT QTYSCAHFER EDMTLEEAQI
60 70 80 90 100
AKIDLALGKL GLQPGMTLLD IGCGWGATMR RAIAQYDVNV VGLTLSKNQA
110 120 130 140 150
AHVQKSFDEM DTPRDRRVLL AGWEQFNEPV DRIVSIGAFE HFGHDRHADF
160 170 180 190 200
FARAHKILPP DGVLLLHTIT GLTRQQMVDH GLPLTLWLAR FLKFIATEIF
210 220 230 240 250
PGGQPPTIEM VEEQSAKTGF TLTRRQSLQP HYARTLDLWA EALQEHKSEA
260 270 280
IAIQSEEVYE RYMKYLTGCA KLFRVGYIDV NQFTLAK
Length:287
Mass (Da):32,724
Last modified:July 10, 2007 - v1
Checksum:i669C3224C6B178C0
GO

Sequence cautioni

The sequence AAC44617 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66108 Genomic DNA Translation: AAC44617.1 Different initiation.
CP000611 Genomic DNA Translation: ABQ72379.1
PIRiA70614
RefSeqiWP_003900985.1, NZ_CP016972.1

Genome annotation databases

EnsemblBacteriaiABQ72379; ABQ72379; MRA_0655
KEGGimra:MRA_0655

Similar proteinsi

Entry informationi

Entry nameiMMAA2_MYCTA
AccessioniPrimary (citable) accession number: A5U029
Secondary accession number(s): P72026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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