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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176UniRule annotation1
Active sitei257Proton donorUniRule annotation1
Active sitei361UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:MRA_0489
OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Taxonomic identifieri419947 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001988 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000028981 – 369UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST369

Interactioni

Protein-protein interaction databases

STRINGi419947.MRA_0489

Structurei

3D structure databases

ProteinModelPortaliA5TZL0
SMRiA5TZL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 202FAD-binding PCMH-typeUniRule annotationAdd BLAST174

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R4N Bacteria
COG0812 LUCA
HOGENOMiHOG000284356
KOiK00075
OMAiAWLIDKA

Family and domain databases

Gene3Di3.30.43.10, 1 hit
3.90.78.10, 1 hit
HAMAPiMF_00037 MurB, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR003170 MurB
IPR011601 MurB_C
IPR036635 MurB_C_sf
IPR006094 Oxid_FAD_bind_N
PANTHERiPTHR21071 PTHR21071, 1 hit
PfamiView protein in Pfam
PF01565 FAD_binding_4, 1 hit
PF02873 MurB_C, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
SSF56194 SSF56194, 1 hit
TIGRFAMsiTIGR00179 murB, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

A5TZL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSGVGSLF AGAHIAEAVP LAPLTTLRVG PIARRVITCT SAEQVVAALR
60 70 80 90 100
HLDSAAKTGA DRPLVFAGGS NLVIAENLTD LTVVRLANSG ITIDGNLVRA
110 120 130 140 150
EAGAVFDDVV VRAIEQGLGG LECLSGIPGS AGATPVQNVG AYGAEVSDTI
160 170 180 190 200
TRVRLLDRCT GEVRWVSARD LRFGYRTSVL KHADGLAVPT VVLEVEFALD
210 220 230 240 250
PSGRSAPLRY GELIAALNAT SGERADPQAV REAVLALRAR KGMVLDPTDH
260 270 280 290 300
DTWSVGSFFT NPVVTQDVYE RLAGDAATRK DGPVPHYPAP DGVKLAAGWL
310 320 330 340 350
VERAGFGKGY PDAGAAPCRL STKHALALTN RGGATAEDVV TLARAVRDGV
360
HDVFGITLKP EPVLIGCML
Length:369
Mass (Da):38,521
Last modified:July 10, 2007 - v1
Checksum:i50AC021602ED9822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA Translation: ABQ72210.1
RefSeqiWP_003402354.1, NZ_CP016972.1

Genome annotation databases

EnsemblBacteriaiABQ72210; ABQ72210; MRA_0489
KEGGimra:MRA_0489

Similar proteinsi

Entry informationi

Entry nameiMURB_MYCTA
AccessioniPrimary (citable) accession number: A5TZL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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