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A5TZG3 (PSD_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:MRA_0442
OrganismMycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]
Taxonomic identifier419947 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Phosphatidylserine decarboxylase beta chain By similarity
PRO_1000026660
Chain200 – 23132Phosphatidylserine decarboxylase alpha chain By similarity
PRO_1000026661

Sites

Site199 – 2002Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2001Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
A5TZG3 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: EA9C65BD41A579B3

FASTA23124,260
        10         20         30         40         50         60 
MARRPRPDGP QHLLALVRSA VPPVHPAGRP FIAAGLAIAA VGHRYRWLRG TGLLAAAACA 

        70         80         90        100        110        120 
GFFRHPQRVP PTRPAAIVAP ADGVICAIDS AAPPAELSMG DTPLPRVSIF LSILDAHVQR 

       130        140        150        160        170        180 
APVSGEVIAV QHRPGRFGSA DLPEASDDNE RTSVRIRMPN GAEVVAVQIA GLVARRIVCD 

       190        200        210        220        230 
AHVGDKLAIG DTYGLIRFGS RLDTYLPAGA EPIVNVGQRA VAGETVLAEC R

« Hide

References

[1]"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000611 Genomic DNA. Translation: ABQ72163.1.
RefSeqYP_001281725.1. NC_009525.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA5TZG3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000068646; EBMYCP00000066756; EBMYCG00000068641.
GeneID5214290.
GenomeReviewsGene locus MRA_0442 in contig CP000611_GR.
KEGGmra:MRA_0442.
PATRIC18140516. VBIMycTub106795_0479.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0688.
GeneTreeEBGT00050000017584.
HOGENOMHBG541103.
OMAIFMSVFN.
ProtClustDBPRK05305.

Enzyme and pathway databases

BioCycMTUB419947:MRA_0442-MONOMER.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_MYCTA
AccessionPrimary (citable) accession number: A5TZG3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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